Biocatalysis with a Synthetic Focus
The Hyster group harnesses the unique reactivity and accompanying high regio- and stereoselectivity of catalytic enzymatic processes to develop synthetically useful organic reactions. Each project is specifically chosen to address challenges in synthetic organic chemistry that are beyond the reach of classical methods. This involves capitalizing on both natural and non-natural reactivity of a myriad of enzyme classes to generate molecular scaffolds with medical and biological relevance.
Members of the Hyster group are trained in synthetic chemistry, organometallic chemistry and chemical biology with a strong emphasis on chemical reaction development. We are actively pursuing graduate students that are interested in research areas including organic synthesis, photoredox catalysis, inorganic chemistry, and chemical biology.
Shining Light on the Field of Biocatalysis
A major area of research focus in the Hyster lab features accessing non-natural enzymatic modes of reactivity through photoexcitation of redox active cofactors or cofactor/substrate complexes in proteins that are cofactor dependent. This approach provides access to enantioselective single electron pathways that are currently unmatched by small molecule organic and transition metal catalysts to date. We envision that this approach will unlock new synthetic pathways to access a range of complex chemical structures in a single synthetic operation.
Identifying Catalytic Synergy with Protein/Catalyst Hybrids