Princeton ACS Section Dinner Meeting
Wednesday, April 17, 2013
our guest speaker will be
Mark J. Strynar, Ph.D.
U.S. Environmental Protection Agency, National Exposure Research Laboratory
“Human Exposure to Persistent Perfluorinated Compounds”
Location: Frick Laboratory, Princeton University
Social mixer: 5:30 pm in CaFe, Taylor Commons
Presentation: 6:30 pm in Taylor Auditorium
Dinner: Immediately following presentation, in café area
Abstract: Worldwide attention has recently been focused on a group of persistent organic pollutants known as the perfluorinated compounds (PFCs). This class of compounds includes perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) and a large number of other structurally related compounds that have been used in a wide range of industrial and consumer applications for the past 5 decades. Concern about these compounds has increased due to a growing number of studies which indicate that some of these compounds are toxic, bioaccumulative, and persistent in the environment. Moreover, the mean half-lives of PFOS and PFOA in humans have been estimated to be 5 and 4 years, respectively.
Recent advances in analytical chemistry have made it possible to measure these compounds in environmental and biological matrices, but the sources of human exposure remain poorly described. This presentation will review some of the latest studies conducted by the USEPA and others to describe our current understanding of how humans are exposed to these compounds. A review of the most recent studies of potential human health effects will also be included.
Disclaimer: Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect the official Agency policy.
Biography: Mark’s expertise is the development of methods for the detection of xenobiotic compounds in particular perfluorinated compounds (PFCs) in complex environmental and biological matrices. Emphasis has been placed on providing the EPA and collaborating researchers with methods for the detection and analysis of PFCs in samples for use in health effects studies to support risk assessment (NIEHS/NHEERL) and for determination of environmental PFC contamination to meet agency needs (OPPT/Region 4). With proper validated methods in place an assessment of dosed animal models has been possible for PFOS and PFOA. In part, provisional health advisories for PFOS and PFOA in drinking water (OW) and fish consumption advisories (State of MN) have been possible due to methods and data I have generated. Developed methods have and will continue to be applied to assess potential routes of human exposure to PFCs to reduce uncertainty associated with these exposures. Recent investigations include development of TOFMS methods for the discovery of biomarkers of exposure to xenobiotic compounds in dosed rodent tissues, and exploration of unique biomarkers in matched human serum/urine.
He has been with USEPA National Exposure Research Laboratory, Methods Development and Application Branch, since 2005. Prior to this he was a Postdoctoral Researcher at the USEPA Methods Development and Application Branch. He received his Ph.D. is Soil Science from the University of Pennsylvania in 2003.
Reservations: The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin at 5:30 pm in the CaFe area of Taylor Commons. The lecture will be held in the Auditorium at 6:30 pm followed by dinner in Taylor Commons (CaFe area). Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane (see www.princeton.edu/main/visiting/ for other parking options). The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Please contact Louise Lawter at firstname.lastname@example.org or 215-428-1475 by April 10 to make reservations. Reservations must be canceled no later than April 16 to avoid being billed for the dinner.