The North Jersey ACS NMR Topical Group and Princeton ACS Section present the 4th Annual NMR Symposium on Wednesday, October 21, 2015 at Princeton University
The afternoon sessions of the 4th Annual NJACS NMR Symposium are followed by the Princeton ACS Meeting (seminar and dinner):
Peter Caravan, Ph.D., Associate Professor of Radiology, Harvard Medical School, Director, Institute for Innovation in Imaging (I3) and Department of Radiology, Massachusetts General Hospital
will speak on “Molecular Magnetic Resonance Imaging”
Frick Chemistry Laboratory, Princeton University, Mixer at 5:30pm; Presentation 6:30 pm followed by dinner.
Traditionally, radiologic imaging has been concerned with questions of anatomy (e.g. bone fractures) or function (e.g. organ perfusion). Molecular imaging adds another layer of information and reports on specific protein expression, enzymatic activity or metabolism, for instance the use of [18F]fluorodeoxyglucose (FDG) to image glycolytic metabolism. Clinical magnetic resonance (MR) imaging offers the benefits of sub-millimeter spatial resolution, high soft tissue contrast, and deep tissue penetration without the need for ionizing radiation. A barrier to molecular imaging with MR is the low sensitivity of the technique, which requires at least micromolar concentrations of the reporter molecule. However with judicious choice of the imaging target and innovative molecular design it is possible to develop robust molecular MR probes. This talk will describe our experience in the design and application of molecular probes for imaging aspects of thrombosis, fibrosis, acidosis, and tissue redox with MRI.
Peter Caravan directs the Institute for Innovation in Imaging (I3) at Massachusetts General Hospital (MGH). The goal of the I3 is to translate new radiological technologies from the preclinical stage into clinical trials and commercialization. Dr. Caravan is a NIH-funded investigator whose research is focused on the development of molecular probes with applications in detection and staging of fibrotic diseases, detection of thrombosis, and characterization of the tissue microenvironment. Prior to joining MGH in 2007, Dr. Caravan was Principal Scientist at Epix Pharmaceuticals and played a leading role in the development of gadofosveset, an FDA-approved MRI probe for blood vessel imaging. He has published over 100 peer-reviewed articles on the design, characterization, and application of molecular probes for use in MRI, PET imaging, and optical imaging. Dr. Caravan is an inventor on over 20 issued or pending patents and is co-founder of Collagen Medical, a company seeking to develop a MR probe for staging fibrotic diseases. He is Deputy Editor of Magnetic Resonance in Medicine and on the editorial boards of Contrast Media and Molecular Imaging, Investigative Radiology, and the Journal of Biological Inorganic Chemistry. He received his B.Sc.(Hons) degree from Acadia University in Nova Scotia and his PhD in Inorganic Chemistry from the University of British Columbia.
The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin at 5:30 pm in the CaFe area of Taylor Commons. The lecture will be held in the Auditorium at 6:30 pm followed by dinner in Taylor Commons (CaFe area). Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane (see http://m.princeton.edu/map/). The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Payment is collected at the dinner. Please contact Louise Lawter at firstname.lastname@example.org or 215-428-1475 by October 16 to make reservations. Reservations must be canceled no later than October 20 to avoid being billed for the dinner. (You can also register for symposium and/or for dinner at http://www.njacs.org/nmr-spectroscopy-topical-group#register-2015-10-21 or by emailing email@example.com)
4th Annual NMR Symposium presented by the
North Jersey ACS NMR Topical Group and the Princeton ACS Section
Wednesday, October 21st, 2015, McDonnell Hall A01, Princeton University, New Jersey
Mei Hong (MIT) – solid-state NMR of membrane proteins
Robert Powers (University of Nebraska – Lincoln) – metabolomics
Hashim Al-Hashimi (Duke) – RNA and DNA dynamics
Kevin Gardner (CUNY) – protein-protein interactions
Mark McCoy (Merck) – structure-based drug discovery
Peter Caravan (MGH/Harvard, Boston) – imaging probes
Register for symposium and for dinner at http://www.njacs.org/nmr-spectroscopy-topical-group#register-2015-10-21 or by emailing firstname.lastname@example.org
Symposium details available at http://www.njacs.org/nmr-spectroscopy-topical-group