Princeton ACS Virtual Meeting
Thursday, October 22, 4:00 pm
Marty Burke, PhD, May and Ving Lee Professor for Chemical Innovation, and Professor of Chemistry,
University of Illinois at Urbana-Champaign
“Making Molecular Prosthetics”
Biography: Dr. Marty Burke is the May and Ving Lee Professor for Chemical Innovation, and Associate Dean for Research, Carle Illinois College of Medicine. Dr. Burke’s group has pioneered the field of molecular prosthetics, and the development of an automated Lego-like platform for democratizing small molecule synthesis. Dr. Burke has received a number of honors and awards, including the Nobel Laureate Signature Award for Graduate Education in Chemistry from the American Chemical Society and has garnered praise for excellence in teaching at both the undergraduate and graduate levels. Dr. Burke, is an Academic Founder/Co-Founder of Revolution Medicines, Ambys Medicines, Sfunga Therapeutics, and cystetic Medicines, and is currently leading the SHIELD team at The University of Illinois, which is performing fast and frequent testing for all of our staff, faculty and students.
Abstract: Most diseases caused by deficiencies of protein function remain outside the reach of modern medicine. Akin to the way imperfect prosthetic limbs can restore substantial function on the macroscopic scale, the Burke lab has recently shown that small molecules capable of imperfectly replicating the function of missing or dysfunctional proteins can restore physiology in a range of cellular and animal models of human diseases, including anemias and cystic fibrosis. A recent clinical trial that administered small molecule-based anion channels intranasally to people with cystic fibrosis also showed promising results. These exciting breakthroughs have laid the foundation for the development of small molecules that restore human physiology by operating as prostheses on the molecular scale. To enable this research, the Burke lab has developed a powerful Lego-like approach for making small molecules involving the iterative assembly of MIDA boronate building blocks. Prof. Burke is the founder of four biotechnology companies: REVOLUTION Medicines, Ambys Medicines, Sfunga Therapeutics and cystetic Medicines. This talk will also discuss the origins of each of these companies and the exciting challenge of translating breakthroughs from the lab and into society.
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