Princeton ACS Meeting – Wednesday, September 30, 2015
Margaret O. James, Ph.D., D.Sc., Jack C. Massey Professor of Pharmacy,, Department of Medicinal Chemistry, University of Florida will speak on
“Biotransformation of Environmental Chemicals in Fish and People”
Frick Chemistry Laboratory, Princeton University. Mixer at 5:30pm in Taylor Commons; Presentation 6:30 pm in Taylor Auditorium followed by dinner in the Commons.
People and animals are exposed in daily life to a variety of foreign chemicals (xenobiotics), ranging from pesticides used to improve crop production to components of personal care products such as toothpaste. Although the intent for use of these chemicals is to provide benefits, further study by toxicologists sometimes reveals unintended side effects of these exposures. This talk will discuss two examples of environmental chemicals, the legacy pesticide, methoxychlor, and the antibacterial additive, triclosan (C & E News 92(25) June 2014). Evidence for possible adverse effects of each will be described, as will their uptake, biotransformation and elimination in fish and people.
Margaret O. James received a B.Sc. (honors) in chemistry from University College London in 1969 and a Ph.D. in bioorganic chemistry from St. Mary’s Hospital Medical School, University of London in 1972. Following post-doctoral studies in pharmacology/toxicology at the National Institute of Environmental Health Studies (1972-5), she was appointed Senior Staff Fellow at NIEHS (1975-80). In 1980, Dr. James joined the faculty of the Department of Medicinal Chemistry, College of Pharmacy, University of Florida, as an assistant professor. She was promoted to associate professor in 1985 and to full professor in 1990. She served as chair of the Department of Medicinal Chemistry from 1991- 2015. She currently occupies the endowed Jack C. Massey Professorship of Pharmacy.
Dr. James’ research interests are in various aspects of xenobiotic biotransformation in aquatic species as well as people. One current research area is the interaction of drugs and environmental chemicals and their metabolites with steroid-metabolizing enzymes. Another interest is factors that influence individual differences in drug metabolism. Dr. James has authored 151 peer-reviewed articles in such journals as Environmental Health Perspectives, Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, Toxicological Sciences, Environment International and Chemico-Biological Interactions, as well as several book chapters. She has been the principal investigator or co-principal investigator of NIH-funded grants since 1983, including serving as director of the University of Florida’s Superfund Research Program from 1995 to 2007.
The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin at 5:30 pm in the CaFe area of Taylor Commons. The lecture will be held in the Auditorium at 6:30 pm followed by dinner in Taylor Commons (CaFe area). Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane (see http://m.princeton.edu/map/). The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Payment is collected at the dinner. Please contact Louise Lawter at email@example.com or 215-428-1475 by September 24 to make reservations. Reservations must be canceled no later than September 29 to avoid being billed for the dinner.