Princeton ACS Meeting,Thursday, March 23, 2017
Mukund Chorghade, Ph.D., President and Chief Scientific Officer, THINQ Pharma / THINQ Discovery will speak on
“Fascinating Excursions into Drug Development:An Insider’s Perspective”
Bowen Hall, Princeton University, Mixer 5:30 pm; Presentation 6:30 pm followed by dinner.
Abstract: While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses have opened new vistas in drug discovery, the industry is facing a serious innovation deficit. Critics suggest that “we have become high throughput in technology, yet have remained low throughput in thinking”. Post marketing failures of blockbuster drugs have become major concerns of industries, leading to a significant shift in paradigms and integration of discovery and process research.
Process Chemistry / Route Selection are pivotal activities in the path of a drug from concept to commercialization. The development of a novel, cost efficacious, scalable processes for chiral molecules, natural and synthetic, will be presented. Also, several problems are currently associated with the use of biological systems in studying drug metabolism. Some novel chemical approaches will be discussed.
Biography: Dr. Mukund Chorghade is a serial entrepreneur, President and Chief Scientific Officer, THINQ Pharma / THINQ Discovery. He is the CSO of Chicago Discovery Solutions, and has had Adjunct Research Professor / Visiting Fellow / Scientists appointments at Harvard, MIT, Princeton, Cambridge, Caltech, Univ. of Chicago, Northwestern, Strathclyde and several other universities. He provides synthetic chemistry and pharmaceutical drug development expertise to academic laboratories, pharmaceutical and biopharmaceutical companies. His current research interests are in Traditional Medicine derived New Chemical Entities and the discovery of the new “chemosynthetic livers” with utility in drug metabolism, valorization of biomass and environmental remediation. He is a Certified CGLP / cGMP professional. Dr. Chorghade earned his B.Sc. and M.Sc. degrees from the University of Poona, and a Ph.D. at Georgetown University. He completed postdoctoral appointments at the University of Virginia and Harvard University.
Reservations: The meeting will be held in Bowen Hall, Princeton University. There will be a social mixer from 5:30 pm – 6:30 pm in the second floor Atrium, directly outside of the Auditorium (Room 222). The lecture will begin in the Auditorium at 6:30 pm and dinner will follow in the Atrium. Bowen Hall is located on Prospect Street, adjacent to the North Garage. Parking is available in the North Garage or on Prospect Street (see http://m.princeton.edu/map/). For elevator access to Bowen Hall second floor, enter from the ground floor entrance facing the North Garage. (From the garage, follow the path around the large white tanks to the ground floor building entrance.) The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Please contact Louise Lawter at email@example.com or 215-428-1475 by March 17 to make reservations. Reservations must be canceled no later than March 22 to avoid being billed for the dinner.
Princeton ACS Meeting, Thursday, April 20, 2017
Florence Ling, Ph.D., Postdoctoral Researcher, Civil and Environmental Engineering Department, Princeton University will speak on
“Treating Acid Mine Drainage with Biomineral Engineering“
Frick Laboratory, Princeton University, Mixer 5:30 pm; Presentation 6:30 pm; Dinner 7:45 pm
Abstract: In Pennsylvania, the state’s history of mining has led to an acid mine drainage problem. Acid mine drainage results in streams with high acidities, the presence of iron hydr(oxide) precipitates, and high dissolved metal concentrations. Precipitated iron (hydr)oxides in affected streams can smother plant and wildlife, disrupting river ecosystems. Treatment of acid mine drainage systems often involve the addition of lime to neutralize the acidity, but the removal of contaminant metals needs to be addressed as well. At several Pennsylvanian acid mine drainage sites that contain high manganese concentrations, metal removal methods are challenged by the environmental conditions required to remove manganese from streamwater as manganese oxide. Using metal removal units developed by EcoIslands LLC, we work to promote the growth of bacteria and fungi in treatment systems that can help overcome environmental barriers for manganese oxide precipitation. Once dissolved manganese is precipitated as a manganese oxide, it is capable of pulling out a range of other contaminants, including Pb, Zn, and Ni. We investigate the promotion of manganese oxide bio-precipitation for acid mine drainage remediation, and how to optimize manganese oxide properties for contaminant uptake. The preferential formation of the layered manganese oxide, birnessite, may increase uptake of contaminants.
Biography: Florence Ling is an Environmental Geochemist, currently working as a Postdoctoral Researcher at Princeton University in the Civil and Environmental Engineering Department. She received her Ph.D. in 2016 from Pennsylvania State University in the Geosciences, and her B.A. in 2011 from Dartmouth College in Environmental Earth Science. Florence’s research focuses on environmental applications of mineral-fluid reactions. She is interested in understanding how various minerals can be used to uptake contaminants in the environment, and how to optimize these processes. During her Ph.D., she examined manganese oxides precipitated at acid mine drainage sites for metal removal. Currently at Princeton, Florence studies barite co-precipitation with hazardous ions for the removal of trace contaminants in fracking water. She is also working on a project that examines carbonate precipitation in the subsurface for the geologic storage of CO2.
Reservations: The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin at 5:30 pm in the CaFe area of Taylor Commons. The lecture will be held in the Auditorium at 6:30 pm followed by dinner in Taylor Commons (CaFe area). Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane (see http://m.princeton.edu/map/). The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Please contact Louise Lawter at firstname.lastname@example.org or 215-428-1475 by April 15 to make reservations. Reservations must be canceled no later than April 19 to avoid being billed for the dinner.
Princeton ACS May Meeting
The ACS Princeton Section and The ACS Philadelphia Section Presents
“Non-Traditional Careers: A Panel Discussion And Networking Event”
Thursday, May 11, 2017, 5:30 pm – 10:00 pm
Bowen Hall Princeton University, Princeton, NJ
Mr. J. P. Northrop (Edward Jones Investments)
Dr. Kevin Cannon (Penn State Abington)
Dr. Mukund Chorghade (THINQ Pharma)
Dr. Molly Hoke (Mallinckrodt Pharmaceuticals)
Dr. Paul Winslow (Students 2 Science)
MODERATOR: Joe Martino (ACS Career Consultant and Presenter)
COST: $25.00 (Includes dinner)
To register, please visit https://acsprincetonphillycareerdiscussion.eventbrite.com. If you have any questions, contact email@example.com
Are you considering stepping away from a traditional chemistry environment and moving toward an exciting career outside of an industrial laboratory? If this describes your situation, then please join us for this informative panel discussion as Joe Martino moderates a conversation with experienced chemists who have done exactly that. We’ll explore transitioning from the industrial laboratory to roles which support the industrial enterprise, academia, non-profits, and even transitioning away from chemistry. Ample opportunity for networking will be provided along with an enjoyable dinner. Please join us!
Bowen Hall is on the campus of Princeton University near the corner of Prospect Avenue and Olden Street. There will be a social mixer at 5:30 pm in the second floor Atrium, directly outside of the Auditorium (Room 222). The lecture will begin in the Auditorium at 6:15 pm and dinner will follow in the Atrium. Bowen Hall is readily accessible from US 1, US 206, NJ 27, I 95 and I 295. Free parking is available beginning at 5:00 PM in the North Garage which is right next to Bowen Hall.
Section Submits 2016 Annual Report
ACS Local Sections are required to submit a report on their activities and finances to the ACS Local Section Activities Committee (LSAC) by February 15 of each year. The online system, FORMS is used for this purpose. Khalid Mahmood, 2016 Chair, completed the Administration form with the help of other PACS Executive Committee members and Committee Chairs. David Carrick, as 2016 Treasurer, completed the Financial form. The report was approved by Councilors Allen Jones and Louise Lawter and submitted to LSAC review by February 15, 2017.
Key features of the report are the summary of 2016 activities by the outgoing Chair and the goals of the 2017 Chair and Chair Elect. These goals are listed below, and a summary by Khalid Mahmood of the Sections activities can be found in the ChemLuminary Awards Article that follows.
George Theodoridis, 2016 PACS Chair listed his goals for the Section:
- Provide the Princeton local section with a series of interesting seminars where chemistry topics are presented and discuss.
- Facilitate chemistry related activities that engage the local community. Examples are Chemagination, Science Café, and National Chemistry Week.
- Develop Career related activities that address job related concerns for local section chemists. Will try to involve other local sections.
And his concerns and challenges:
- Some of my concerns involve the need to broaden our reach to include a larger number of local section members. Also, I would like to increase the interactions with local communities.
Susan VanderKam, 2017 Chair-Elect, listed her goals for the Section:
- To continue to find interesting and relevant speakers for monthly sectional meetings
- To engage the students in the section, graduate, undergrad, and HS, through outreach and programming
- To update the social media, website, and communication of the local section
And her concerns and challenges:
- In order to maintain and grow the membership, the younger generation must be engaged and contributing. We must keep the visible presence (social media, communication, websites) up to date and work on activities that will include them directly, both as volunteers for outreach and as the audience for career building programming.
Section Self-Nominates for Five ChemLuminary Awards!
Each year, local sections have the opportunity to self nominate for ChemLuminary Awards that recognize sections for exemplary programming during the previous year. PACS chose to self-nominate three of its 2016 activities for awards: Chemagination, a competition for high school students, our STEM Outreach and Entrepreneurship Program, a new program for us in 2016 and our 2016 National Chemistry Week Activities Night.
The selected awards are:
Program: Princeton American Chemical Society STEM Outreach and Entrepreneurship Program
- Award: Outstanding Local Section Career Program Award
- Sponsor: Committee on Corporation Associates
- Award Description: These awards recognize Local Section Career programs that have contributed significantly to ACS members’ career management and development.
- Award: Outstanding Local Section Career Program Award
- Sponsor: Committee on Economic and Professional Affairs
- Award Description: This award has recognizes Local Section Career programs that have contributed significantly to ACS Members’ career management and development.
- Award: Most Innovative New Activity or Program
- Sponsor: Committee on Local Section Activities
- Award Description: this award honors a local section that initiated a unique activity or program in 2016. A local section can nominate only one activity or program for this award.
Program: Chemagination at Princeton, Annual Local Section Competition
- Award: Outstanding High School Student Program Award
- Sponsor: Society Committee on Education
- Award Description: This award is designed to recognize local sections that have organized or sponsored outstanding chemistry programs for high school students, such as the U.S. National Chemistry Olympiad (USNCO) program, science fairs, or chemistry clubs.
Program: National Chemistry Week 2016 “Chemical Mysteries” Activities Night
- Award: Outstanding On-going NCW Event
- Sponsored by Committee on Community Activities
- Award Description: Recognizes a local section for an outstanding event that has been conducted for at least three years (not awarded to the same section more than once in a 5 year period).
And finally, based on the quality and number of our activities in 2016, the Section also self-nominated for :
Section: Princeton Section of the ACS
- Award: Local Section Outstanding Performance Award
- Sponsor: Committee on Local Section Activities
Year 2016 was a productive year for Princeton Section of American Chemical Society (PACS). The unique programming highlight for this year was a STEM program for high school students. The program was proposed and conducted by a graduate student of Princeton University, Christin Monroe. The program consisted of multiple days of activities spanning multiple sites and cities during August, 2016. Students from area high schools competed in winning a limited number of seats available in this program. The program culminated in a chemistry show by past ACS President Bassam Shakashiri and a networking dinner for the program participants and volunteers. Happiness and enthusiasm of participating High School students and their parents was worth noting. Princeton section of ACS honored the success of this program by nominating Christin Monroe for a “Volunteer of the Year” award.
Princeton Section also conducts other successful programs every year. Among those recurrent programs worth mentioning are:
- Chemagination Competition for High School students. This program is managed by Barbara Ameer and her team of volunteers. Year after year we have seen young students competing through their imagination predicting future of science and technology. This year was no exception and the icing on the cake was that we saw a record number of team participation from various local high schools
- National Chemistry Week: The program Chair is Kitty Wagner of Princeton University and a leader of Princeton ACS. She has conducted this program for more than 15 years. Every year has been better than previous year from the participation, community interest, volunteer participation or program diversity.
- Science Café: This is a relatively new program championed by Randy Weintraub about five years ago. This program is unique because it has a target audience of all ages and backgrounds including the general public with no or little science background. The program in 2016 highlighted the role of science in four spheres of human activity: Academia, Politics, Culinary Art and Community Service. Among guest speakers were a Professor turned state politician and a Science graduate turned Chef and back to part time academia-part time businessman.
- Recurrent Dinner / Seminar Meetings: As planned we had dinner / seminar meetings throughout the year except for two months in the summer. The various themes and speakers are described under the Event – PACS Monthly Meetings section of FORMS.
- Numerous activities in collaboration through local schools: The section is regularly participating in science activities held by local schools at their campuses from middle to high schools. This has been a very effective method of outreach to an extended community of young minds.
In summary, the Princeton Section has held several successful activities this past year to serve diverse audiences and is deserving of the Local Section Outstanding Performance Award!
PACS at Lawrence Science Fair
On Saturday, February 25, the Princeton ACS Section (PACS) participated in the Lawrence Intermediate School Science Expo, which attracted about 400 children and parents. Allen Jones organized and chaired the PACS activities. In a thank you note to volunteers Alex Ramadan, Christin Munroe, George Theodoridis, and Ted Schaaf, Allen wrote “We were able to provide six activities which demonstrated a variety of interesting scientific principles: chromatography, simple batteries, cold energy to light, spectral analysis, fluorescence and phosphorescence, and sunscreen effectiveness. Feedback from both demonstrators and participants was overwhelmingly positive. Everyone had a great time; the kids and their parents were really engaged, as were several college students.”
See photos from this event and others on our website home page photo gallery http://chemists.princeton.edu/pacs/
2017 Spring Symposium and Vendor Exhibition Sponsored by the
North Jersey American Chemical Society Drug Metabolism Discussion Group
“Translating Preclinical Drug Disposition in Clinical Development”
The Palace at Somerset Park, April 20, 2017, 8:00 am – 3:45 pm
|8:00 a.m.||Registration / Continental Breakfast / Vendor Exhibit|
|9:00 a.m.||Introductory Remarks
Bo Wen, Chair, NJ DMDG
|9:10 a.m.||Metabolomic and Transcriptomic Analysis of BCRP/Abcg2 and PGP/Abcb1 WT and Double KO Rat Tissues to Identify Endogenous, Dietary and Xenobiotic Substrates
Erin Schuetz, PhD, Member, Department of Pharmaceutical Sciences, St Jude Children’s Research Hospital, Memphis, TN
|10:00 a.m.||Assays to Guide the Way at NCATS: Drug Transporters and Drug Efficacy
Matthew Hall, PhD, Biology Group Leader, National Center for Advancing Translational Sciences (NCATS) Chemical Genomics Center, National Institutes of Health, Rockville, MD
|10:45 a.m.||Vendor Exhibit & Coffee Break|
|11:30 p.m.||Emerging Role of Non-P450 Enzymes in Drug Metabolism and Toxicity
Deepak Dalvie, PhD, Sr. Principal Investigator, Department of Drug Metabolism and Pharmacokinetics, Celgene, San Diego, CA
|12:15 p.m.||Lunch & Vendor Exhibit|
|1:45 p.m.||Is it Possible to Accurately Predict the Risk that a Drug Candidate Will Cause Idiosyncratic Drug Reactions?
Jack Uetrecht, PhD, Professor of Pharmacy and Medicine and the Canada Research Chair in Adverse Drug Reactions, University of Toronto, Toronto, Ontario, Canada
|2:30 p.m.||Vendor Exhibit & Coffee Break|
|3:00 p.m.||ADME Analysis of Therapeutic Peptides: Preserving Product Value
Jerome Hochman, PhD, Sr. Principal Scientist, Department of Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co. West Point, PA
|3:45 p.m.||Program Closure|
Pre-registration fee is $125 (pre-register by April 15, 2017). Registration fee at the door is $150 (Checks only). Registration fee for students and postdocs is $10 and $50 for faculty. Registration is free for unemployed. To register and for more information.visit our website: http://www.njacs.org/topical-groups/drug-metabolism
Exhibitors: Please contact Anima Ghosal ( firstname.lastname@example.org ) for information concerning exhibits
Welcome to MARM 2017
Submit your abstract for the 2017 Mid Atlantic Regional Meeting
June 4-6, 2017 in beautiful Hershey Pennsylvania!
ABSTRACT SUBMISSION DEADLINE IS MARCH 20, 2017
AWARDS SUBMISSION DEADLINES BEGIN MARCH 1, 2017
The theme is “Elements of Transition,” which was inspired by the many changes happening on different fronts. New sources of energy, renewed interest in STEM programs, the varying business models in the pharmaceutical industry, and the new opportunities that come with changing regulations are just some of the transitions we feel will provide discussion topics for a wide swath of businesses and individuals in the Mid-Atlantic region.
For more information on the technical see http://marm2017.sites.acs.org/technical.htm
Going to #MARM2017?
Use our hashtag to enter your students in a prize drawing
Our twitter is @MARM2017_ACS
253rd American Chemical Society
NATIONAL MEETING & EXPOSITION
Advanced Materials, Technologies, Systems & Processes
APRIL 2-6, 2017 | San Francisco, CA