North Jersey & Princeton ACS Event: NJACS NMR Symposium, PACS Monthly Meeting and Joint Career Forum
Monday, September 24, 2018, Frick Chemistry Laboratory, Princeton University
A combined NJACS NMR Symposium, PACS Monthly Meeting and joint Student Career Forum will be held on Monday, September 24. The NMR Symposium and Student Career Forum will both be held from 1:00 pm to 5:45 pm. The evening session of the symposium will start at 6:00 pm and will also serve as the Princeton ACS monthly meeting.
Symposium and Career Forum attendance is free; cost for dinner is $20 employed; $15 unemployed/retired; $10 students. Advance registration is required for the Symposium, Career Forum and/or for dinnerTo make dinner reservations and for more details go to http://www.njacs.org/nmr-spectroscopy-topical-group. If you have questions or prefer to make reservations by email contact Louise Lawter email@example.com
Student Career Forum – (Its Not Just for Students!)
The afternoon career forum is designed to provide career information, and guidanceto students as well as professionals interested in enhancing their skills in this area. You may choose to participate in one or more of the modules:
*ACS Career Pathways Course – “Résumé Development: Marketing Your Brand for an Industrial Chemistry Position”. Discover the best way to find jobs in industry and receive some valuable tips for writing a winning resume / CV / cover letter and acing a job interview. Course presenter is Mukund Chorghade, President and Chief Scientific Officer, THINQ Pharma / MVRC Research/ Chicago Discovery Solutions.
*Resume Building– Hands on assistance and practical guidance for resume writing will be provided by experienced professionals. Participants in the Career Pathways course listed above will have the opportunity to practice what they have been taught. Bring your draft resume for review and advice!
*Chemistry Career Conversations– This is anopportunity to network with chemistry professionals to learn about career opportunities and insights. Representatives from companies such as BMS, Merck, Bruker/Biospin, JEOL, New Era Enterprises, and Nexomics and will be participating.
PACS Monthly Meeting Segment & Symposium Keynote Speaker, Taylor Auditorium, 6:00 pm
Dr. Dorothee Kern, Brandeis University will speak on “NMR at its Best: Evaluation Of Protein Dynamics – Time Travel to the Past and Future”
Biography: Dorothee Kern is currently Professor of Biochemistry at Brandeis University and an Investigator of the Howard Hughes Medical Institute since 2005. Dorothee received her PhD at the Martin Luther University in Halle, Germany and conducted her postdoctoral studies at UC Berkeley. In 1999, Dorothee joined the faculty at Brandeis University. Her research group focuses on the dynamical nature of proteins, with the ultimate goal to reveal the interplay between structure, dynamics, and function. As a major contributor in experimental characterization of protein dynamics during enzyme catalysis and signaling, she seeks to apply this understanding of dynamics and allosteric networks to drug discovery. Towards this end, Dorothee is a founder of RelayTherapeutics.
NMR Symposium Schedule, Taylor Auditorium
1:00 pm – Nate Traaseth, New York University, NMR Studies of Transporters and Receptor Tyrosine Kinases
1:40 pm – Rafael Brüschweiler, Ohio State University, New Metabolomics Methods for the Determination of Known and Unknown Metabolites
2:20 pm – Clark Ridge, Food & Drug Administration, Insight from 2-Norbornene, α-Pinene and β-Pinene Experiments on the Shielding Effect of Double Bonds
3:00 pm – Andrew Lee, University of North Carolina, Chapel Hill, Study of Allosteric Detail in Protein Homodimers from NMR
3:40 – 4:20 pm – Coffee Break
4:20 pm – Paolo Di Lello, Genentech, Discovery and Characterization of Small Molecule Fragments that Bind and Inhibit Ubiquitin Specific Protease 7 (USP7)
5:00 pm – David Rovnyak, Bucknell University, NMR Reveals Biomarkers and Classification Strategies for the Complex Progression of Non-Alcoholic Fatty Liver Disease
Princeton ACS Meeting & Graduate Student Awards Seminar
Tuesday October 16, 2018
Frick Chemistry Laboratory, Princeton University
Mixer 5:30pm; Presentation 6:30pm; Dinner 7:45pm
Speakers: Clarissa C. Forneris & Kevin Speina, Princeton University
Clarissa Forneris – “In Vitro Reconstitution of Native P450s Activities Enables Total Chemo-Enzymatic Syntheses of Vancomycin Aglycone Variants”
Abstract:Glycopeptide antibiotics (GPAs) are indispensible for the treatment of life-threatening infections caused by Gram-positive bacteria, especially methicillin-resistant S. aureus.The founding member of this antibiotic class, vancomycin, has been in clinical use since 1948 and, to this date, it is known as the drug of last resort. As inevitable resistance to current antibiotics spreads among pathogenic bacteria, it will be necessary to have a constant supply of new treatments to replace them. Synthetic derivatization of known natural products is the most successful way to create more potent antibiotics, but this approach has been restricted within the GPAs, due to their size and chemical complexity. Three post-translational modifications (PTMs) to the GPA core peptide provide functional shape and rigidity to the molecule. In vancomycin, two bisaryl ether crosslinks and a biaryl carbon-carbon bond are installed by the cytochrome P450 enzymes OxyB, OxyA and OxyC, in this order. It has been hypothesized that if the enzymatic activity of these enzymes could be reconstituted in vitro, a route to the facile synthesis of vancomycin and analogs would be opened. Towards that goal, we have developed a novel strategy to synthesize the coenzyme A adduct of the vancomycin precursor peptide, which is the substrate for the P450 enzymes. After establishing activity for OxyB, we have, for the first time, reconstituted the in vitro activity of OxyA, creating the second bisaryl ether bond and bicyclic vancomycin core. In studying the substrate specificity of OxyA, we have also clarified the order of PTM steps in the biosynthesis of vancomycin. Recently, we reconstituted the activity of OxyC in vitro, thereby finalizing the chemo-enzymatic synthesis of the vancomycin scaffold, a long-standing goal. We have successfully prepared a vancomycin core analog and are currently pursuing synthesis of variants that have been shown to be more potent than the parent compound.
Biography:Clarissa is a 5th year graduate student in the group of Prof. Seyedsayamdost at Princeton University. She is a native of Brazil and moved to Cambridge, MA to carry out her undergraduate studies at Massachusetts Institute of Technology (MIT), where she received a B.S. in Chemistry in 2013. While at MIT, she worked with Prof. Danheiser on synthetic applications of benzannulation reactions. During her graduate studies, she has developed a chemo-enzymatic strategy to synthesize vancomycin, the antibiotic of last resort, and its analogs. The synthetic scheme relies on utilizing the native P450 metalloenzymes to catalyze the formation of key crosslinks that give vancomycin its shape and potent bioactivity. She is currently working on expanding the substrate scope of vancomycin’s biosynthetic P450 enzymes to produce novel analogs and on elucidating the mechanisms of transformations they catalyze.
Kevin Speina – “Towards Commodity Scale Production of Ketones Using a Resilient Fungal Heme Protein”
Abstract:The non-reactive nature of aliphatic C-H bonds makes catalytic oxyfunctionalization, under ambient conditions profoundly difficult. Overcoming this challenge has the potential of transforming low cost, abundant hydrocarbons (i.e. methane, cyclooctane) into low cost precursor molecules capable of derivatization; an industrially advantageous enterprise. Fortunately, nature evolved enzymatic catalysts able to perform oxygenation onto relatively inert C-H bonds. Cytochrome P450s (P450) are a class of monooxygenases that incorporate molecular oxygen onto aliphatic C-H bonds with remarkable regio and stereoselectivity. Within the P450 active site lies an iron protoporphyrin IX with a cysteinate axial ligand. Unfortunately, P450 enzymes require a prohibitively expensive cofactor NAD(P)H and reductases to perform C-H activation chemistry. A class of enzymes known as fungal aromatic peroxygenases (APOs) circumvents this limitation by using H202 as a co-substrate to perform C-H functionalization reactions. APO enzymes are stable, extracellular, glycosylated proteins that have no sequence homology to P450 analogs, yet have enhanced reactivity to P450 enzymes. Herein, a recently identified APO from Marasmius rotula [MroAPO] was found to be stable in the presence of organic solvents such as acetonitrile and acetone (up to 50v%). Even more remarkable is its propensity to form ketones from alkanes in high yields. Simply by adding 0.05% mol of MroAPO in 30v% acetone with excess oxidant, alkane substrates such as cyclooctane and decane are transformed to the corresponding ketone products with high yields. A total turnover number (TTN) of 50000 was calculated for cyclooctane oxidation. This is the second highest TTN reported for cyclooctane. Astonishingly, enzymatic reactions with C12-C6 linear alkanes results in the 2-ketone product, with minute amounts of side products. The 2-ketone products are desirable for the fragrance and food industries. Thus, the reactions catalyzed by MroAPO enzymes have promising biotechnical potential insofar their versatility is unmatched to any known catalyst.
Biography: Unavailable at this time
Reservations:The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin at 5:30 pm in the CaFe area of Taylor Commons. The lecture will be held in the Auditorium at 6:30 pm followed by dinner in Taylor Commons (CaFe area). Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane (see http://m.princeton.edu/map/).The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Please contact Louise Lawter at firstname.lastname@example.org or 215-428-1475 by October 11 to make reservations. Reservations must be canceled no later than October 15 to avoid being billed for the dinner.
Section Wins ChemLuminary!
Om May 11, 2017 he Princeton and Philadelphia ACS Sections co-hosted a Career Panel Discussion on non-traditional chemistry careers at Princeton University. The discussion, which was moderated by ACS Career Consultant Joe Martino, featured the following panelists:
- Kevin Cannon (Penn State University, Abington Campus)
- Mukund Chorghade (THINQ Pharma)
- Molly Hoke (Mallinckrodt Pharmaceuticals)
- J. P. Northrop (Edward Jones Investments)
- Allen Jones (Students 2 Science)
This past February, the Princeton and Philadelphia ACS Sections both self-nominated this activity for the “Outstanding Local Section Career Program” ChemLuminary Award sponsored by Committee on Economic and Professional Affairs to recognize Local Section Career programs that have contributed significantly to ACS Members’ career management and development.
We are pleased to report that the Sections were chosen as joint winners! Plaques werepresented to section representatives at the ChemLuminary Award Ceremony held at the 256th ACS National Meeting in Boston, MA on Tuesday, August 21.
News from National Meeting
The 256th ACS National Meeting was held in Boston, Massachusetts from August 19-23, 2018.Below are highlights of Council Actions. The full summary can be found on our website at http://chemists.princeton.edu/pacs/category/news/acs-national/
Election Results: Elected Committees
- By electronic ballot, the Council elected Ella L. Davis, Lissa A. Dulany, Lisa Houston, and Martin D. Rudd for three-year terms (2019-2021), and Will E. Lynch for a one-year term (2019) on the Council Policy Committee (CPC).
- By electronic ballot, the Council elected Allison Aldridge, Christopher J. Bannochie, Mary K. Engelman, Silvia Ronco, and Frankie K. Wood-Black for three-year terms (2019-2021) on the Committee on Nominations and Elections (N&E).
- By electronic ballot, the Council elected Rodney M. Bennett, Jacqueline A. Erickson, Judith M. Iriarte-Gross, Donivan R. Porterfield, and Carolyn Ribes for three-year terms (2019-2021) on the Committee on Committees (ConC).
Other Council Actions:
Amendments to the ACS Bylaws
- A recommendation by the Committee on Membership Affairs that Council approve the Petition on International Chemical Sciences Chapters achieved the two-thirds majority required to amend Bylaw XI, Section 3 accordingly (additions underlined;deletions struck through):
Affiliations of SOCIETY Local Sections or Divisions shall become effective upon authorization by their governing body, approval by their respective Council committees governing Local Sections and Divisions,and byconfirmation by the Council Committee on Constitution and Bylaws acting for the Council, that the provisions of Section 1 of this Bylaw are met.
The changes will become effective upon confirmation by the Board of Directors.
- A recommendation by the Committee on Membership Affairs that Council approve the Petition on International Chemical Sciences Chapters achieved the two-thirds majority required to amend Bylaw IX, Section 4 accordingly (additions underlined;deletions struck through):
An International Chemical Sciences Chapter shall receive no allotment of funds from the SOCIETY and shall not be entitled to elected representation on the Council. A Chaptermay assess its memberslocal Chapterdues to be expended for its own purposes in harmony with the objects of the SOCIETY.
The changes will become effective upon confirmation by the Board of Directors.
President Dorhout introduced and led a special discussion on what role(s) ACS should play in preventing sexual harassment in the sciences.
To further inform the discussion and Councilor input, a brief survey was conducted using the audience electronic response system. The results of the survey are listed below. The ACS Volunteer/National Meeting Attendee Conduct Policy was in the Council Agenda, and can be found online at [http://www.acs.org/content/acs/en/about/governance/councilors.html].
Have you ever witnessed or experienced sexual harassment at an ACS meeting or ACS event? (413 responses)
Yes 23% (94) No 77% (319)
Have you ever witnessed or experienced sexual harassment at an ACS meeting or ACS event, or in your professional workplace or learning environment? (182 women / 223 men responded)
Yes 77% (141) 57% (127)
No 23% (41) 43% (96)
How familiar are you with the ACS Codes and initiatives for professional conduct? (417 responses)
Very Familiar 38% (157)
Vaguely Familiar 46% (192)
Not Familiar 16% (68)
Has your local section or division instituted a sexual harassment policy of its own? (419 responses)
Yes 3% (12)
No 73% (309)
Don’t Know 23% (98)
Highlights from Committee Reports
Budget and Finance
The Society’s 2018 Probable 1 Projection calls for a Net from Operations of $31.8 million. This is $1.3 million favorable to the Approved Budget. Total revenues are projected to be $565.1 million, which is $5.7 million or 1.0% favorable to the Budget. Total expenses are projected at $553.3 million, which is $4.4 million or 0.8% unfavorable to the Budget. Additional information can be found at www.acs.org, at the bottom of the page, click ‘About ACS’, then ‘Financial’.
Boston Meeting Attendance
As of Tuesday evening, August 21, attendance was:
Expo only 576
As of August 21, ACS had 149,584 members, which is a decline of only eight-tenths of one percent from the over 150,000 members in 2017. This year-to-date figure represents an increase of over 1,200 members when compared to the last two years.
2018 NCW Illustrated Poem Contest – Chemistry is Out of This World
The Princeton Local Section of the American Chemical Society (ACS) is sponsoring an illustrated poem contest for students in Kindergarten through 8th grade in comjunction with National Chemistry week.
Contest Deadline: Poems and entry forms must be received by Friday, October 16, 2018.
Prizes: Prizes will be awarded in K-2nd; 3rd-5th and 6th-8th grades categories.
Contact: Mail or email submissions to Louise Lawter, 475 Prince William Ct., Yardley, PA 19067, email: email@example.com.
Winners of the Princeton Local Section’s Illustrated Poem Contest will advance to the National Illustrated Poem Contest for a chance to be featured on the ACS website and to win prizes!
Write and illustrate a poem using the NCW theme, “Chemistry is Out of This World.” Your poem must be no more than 40 words and in the following styles to be considered:
HAIKU – LIMERICK – ODE – ABC POEM – FREE VERSE – END RHYME – BLANK VERSE Possible topics related to space chemistry include: Light Stars Atmosphere Spectrum Planets Gases Supernova Ultraviolet
Entries will be judged based upon:
- Artistic Merit – use of color, quality of drawing, design, and layout
- Poem Message – fun, motivational, inspiring about yearly theme
- Originality Creativity – unique, clever and/or creative design
• Neatness – free of spelling and grammatical errors
Contest rules and entry forms can be found at:
National Chemistry Week Activities Night: Call for Volunteers
We expect more than 500 guests for NCW Activities Night at Frick Chemistry Laboratory, Princeton University, 6:30-9:30 pm, Friday, October 26, 2018. This year’s theme is “Chemistry is Out of This World.” Activities will be related to the chemistry and material science of space, space exploration, and space travel. Volunteers are needed on October 26 to supervise activities and give short presentations. Volunteers are also needed to help with set-up, registration, and clean-up, to serve as guides, and to take auditorium tickets. (Auditorium presentations will be given by a special guest.) The schedule is given below.
|Time||Place in Frick||Tasks|
|3:00-6:15 pm||Atrium, A02, A03||Set-up for hands-on activities, demonstrations, displays|
|5:00 pm||A57||(Food delivered for volunteers. Eat when you have time.)|
|6:00 pm||Atrium, A02, A03||One or more supervisors for each activity finish set-up and get ready for Group 1 guests|
|6:00-7:00 pm||North door||Registration:Group 1 check-in, auditorium tickets for 6:30 and 7:30 (Send 6:30 auditorium presentation guests directly to auditorium)|
|*6:30-7:00 pm||B02 Taylor Auditorium||*Auditorium presentation 1|
|6:30 pm||Atrium, A02, A03||Hands-on activities and presentations begin|
|7:15-8:30 pm||North door||Registration:Group 2 check-in, give out remaining auditorium tickets|
|*7:30-8:00 pm||B02 Taylor Auditorium||*Auditorium presentation 2|
|8:05-8:25 pm||B02 Taylor Auditorium||NCW Illustrated Poem Contest Awards|
|*8:30-9:00 pm||B02 Taylor Auditorium||*Auditorium presentation 3|
|9:15-9:30 pm||Atrium, A02, A03||End hands-on activities|
|9:30 pm||Event ends|
|9:30-11:00 pm||Atrium, A02, A03, A57||Clean up|
Volunteers are also needed before October 26 to prepare materials and make posters and displays. Program suggestions for activities related to space and suitable for ages 5 and up are very welcome. We aim most activities at ages 8-12.
If you are available to help in any way on or before October 26, or if you have program suggestions, please contact Kitty Wagner, firstname.lastname@example.org, as soon as possible.
Planning for 2019 PACS Elections
The election for Princeton ACS Section Executive Committee Members will be taking place in October 2019.
The PACS Executive Board reviewed and conditionally approved an initial slate of candidates for 2019 Chair-Elect (from Academia) Secretary, Treasurer and new Member-at-Large position.
If you wish to nominate additional candidatesgo to our website at http://chemists.princeton.edu and complete the Nomination Form for 2019 PACS Officers, or click this link: http://chemists.princeton.edu/pacs/pacs-events/pacs-other-events/nominations-for-2019-pacs-elections/
Submissions must be received by September 28, 2018. Self-nominations are also welcome. Candidates are required to be a member of the Princeton ACS Section.
Questions?Email to Khalid Mahmood, email@example.com
Bonding C to Shining C” Conference
We are delighted to inform you about the “Bonding C to Shining C” conference being organized by THINQ and its triad of academic / industrial / government collaborators in Mumbai, India on January 9-11, 2019.
Key goals of the conference
- Increase appreciation of Chemistry in meeting societal needs.
- Generate enthusiasm for the future of Chemistry.
- Celebrate and stimulate creativity, entrepreneurship and innovation
- Stimulate interest in Chemistry among young people and build knowledge collaboration networks
- Deriving inspiration from Mother Nature; Natural products for discovery
- Discovery and Development: Observational Therapeutics and Chemistry of Traditional Medicine
- Precision Medicine and Agriculture
- Food as Medicine
- Route selection and process chemistry driven discovery
- Chemical Biology, Biochemistry, Molecular Biology and Cell Biology
This meeting is unique in being led by industry. The role of Chemistry and Biology in understanding our natural environment has been the focus of attention among scientists and non-scientists alike. This meeting of great minds will provide a unique forum and a veritable banquet of ideas for discussion of the latest advances in Science: a glittering array of scientific luminaries from around the world will participate and inspire! Please enjoy the promulgation of new wisdom and the exploration of this exciting venue and city.
Cosponsorships have been applied for with many of the leading chemical societies, science academies and industrial organizations in the world. Prominent among these international scientific societies are the ACS, RSC, ISCB, AFMC, EFMC and the IUPAC. Several Indian scientific organizations such as INSA, ISCB, CRSI will be invited to be honored cosponsors.
Please contact firstname.lastname@example.org email@example.com for additional details.
The website www.bc2sc.online is a resource for up to date details.
Local Events Calendar
– Chemical Consultants Network Meeting, September 12, 2018
QUICK START GUIDE TO BECOMING A CONSULTANT – Chris Owens – OppNex
Networking, 5:30 PM; Dinner, 6:30 PM; Talk and Business Session, 7:30 PM
Location: The Cynwyd Club, 332 Trevor Lane, Bala Cynwyd, PA 19004
Abstract: Please join us for a “Soup-to-Nuts” perspective on how to set up, organize, and operate your consulting practice, including techniques to sustain business, mitigate risks, and ensure delivery/payment.
Reservation: to register or for more information go to http://chemconsultants.org/event-3024344 or e-mail CCNReservations@aol.com or call the CCN phone number at (267) 666-0949 and leave a message. Fee, including food and beverages (wine, beer & sodas), is $30 by reservation/cancellation deadline: Saturday, Sept 8th.
– ACS Career Day Philadelphia – Saturday, September 15, 2018.
Temple University Science Education Resource Center (1801 N. Broad St., Philadelphia, PA 19122)
Time: 9:15 am to 3:30 pm
It will include career focused workshops, interactive networking sessions and one-on-one career consultation. The ACS Career Day Philadelphia is part of series of local career fairs that are planned for 2018. The intent of these local fairs is to deliver ACS career services which have traditionally been delivered at ACS National Meetings to jobseekers and employers in their local communities. The event will be open to all members in Philadelphia and neighboring local sections. More details can be found here: https://www.acs.org/content/acs/en/careers/career-fair/philadelphia.html
– 2018 North Jersey Chromatography Group (NJCG) Symposium, September 26th, 2018
The 2018 North Jersey Chromatography Group Symposium, wlll be held on Wednesday, September 26th,2018,from 1:00 pm to 6:00 pm at the DoubleTree hotel in Somerset, New Jersey. The theme of the symposium is The Modernization of Chromatographywith a focus on the analytical method lifecycle. The 2018 NJCG Symposium will provide an excellent forum for scientific discussions and social networking in a highly motivated and friendly environment. For detaisl and to register go to http://www.njcg.org/upcoming_meeting.
– Trenton ACS Safety Video Contest
The Trenton local section is holding a Chemical Safety Video Contest and invites members of the community to submit educational safety videos for the contest There will be a call for submissions, the opportunity to interact with top chemical safety experts from the ACS, and chances to win awards! Outstanding videos will be recognized at an awards ceremony in multiple categories including “best picture”.
For more information contact firstname.lastname@example.org. (See http://chemists.princeton.edu/pacs/pacs-events/trenton-acs-section-chemical-safety-video-contest/