Princeton ACS Graduate Student Awards Seminar &
Recognition of Princeton Univ. Dept. of Chemistry by ACS HIST Division for Research Discoveries of Professor Henry Eyring (1934)
Tuesday September 24, 2019
Frick Chemistry Laboratory, Princeton University Mixer 5:30pm; Presentation 6:30pm; Dinner 7:45pm
Mia Borden – “Enantioselective Ni-Catalyzed Reductive Coupling of Benzylic Acetals “
Abstract:The prevalence of α-substituted ethers in pharmaceutically relevant molecules makes the development of robust methods for their synthesis an attractive challenge. An asymmetric Ni-catalyzed cross-electrophile coupling of benzylic acetals with aryl halides has been developed, enabled by a bis-oxazoline ligand. The acetal is converted via ionization to an oxocarbenium ion followed by single electron reduction to an α-oxy radical, which can then engage in cross coupling with the aryl halide using a Ni catalyst. Ongoing work is focused on expanding the scope of acetals and electrophilic couplings partners that can be utilized in this reaction manifold. Multivariate linear regression techniques and organometallic synthesis have been leveraged to understand both the ligand effects and substrate effects on the selectivity of this transformation. Additionally, computational evidence for the mechanism for enantio-induction has been acquired. Given the generality of the Ni/BiOx platform for enantioselective catalysis, efforts are being made to apply the mechanistic gained in the acetal system to other reductive couplings for which an asymmetric variant has remained elusive.
Biography:Mia grew up in Sudbury, Massachusetts. She attended Carleton College (BA, Chemistry 2013), where she worked in Prof. Steve Drew’s group synthesizing and characterizing platinum-based materials for the detection of benzene gas. After college, Mia moved to Seattle and conducted research on cellular aging in the lab of Dr. Dan Gottschling at the Fred Hutchinson Cancer Research Center. Currently, Mia is a Ph.D. candidate in the laboratory of Prof. Abby Doyle. She is a recipient of the Princeton ACS Section’s Recognized Graduate Student Speaker Awards.
Zhaoyue Zhang – “Different Metabolic Pathways Support Lipogenesis in Fat Versus Liver” “
Abstract:Fat, as one of the 3 major nutrients, is the only form of energy for long-term storage in mammals. Dietary fat can be stored directly, while lipogenesis has long been known as a pivotal way to dispose extra energy from carbohydrate, but the importance and mechanism of this fundamental pathway remains unclear. Moreover, being the nutrients with the highest energy density, fatty acids store energy via reduced carbon and hydrogen, but the direct sources of them are still unknown. Here, we developed a systematic method with 13C and 2H isotope tracing to quantify whole-body de novo lipogenesis (DNL) in vivo. Surprisingly, DNL is the most active in liver and brown adipose tissue (BAT) with totally different mechanism. In healthy mice, circulating glucose can only be directly utilized by BAT while liver prefers circulating lactate and acetate. This situation will only change until they got NAFLD, where glucose starts to fuel hepatic DNL directly. Meanwhile, the well-known dominant cytosolic NADPH producer, oxPPP, is only functional in adiposity DNL. Hepatic DNL, instead, prefer one-carbon metabolism, and the change of one-carbon metabolism affects DNL rate. Those findings not only changed the classical point of view in DNL, but also provided new possible solutions to NAFLD.
Biography:Zhaoyue Zhang is a 5th year graduate student in the laboratory of Professor Joshua Rabinowitz, Princeton University. The focus of her research is the in vivo quantitative analysis of liver DNL. In 2015, Zhaoyue complete her bachelor’s degree in chemistry with honor from Peking University, together with a minor in Psychology. Besides academic life, she also worked as a university administrative fellow (UAF) to initiate a variety of activities for the graduate students. She is a recipient of the Princeton ACS Section’s Recognized Graduate Student Speaker Awards.
Reservations:The meeting will be held in Frick Laboratory, Princeton University. The social mixer and dinner will be in the CaFe area of the atrium and the lecture in the Auditorium (B02). Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd. Parking is available in Lot 21, corner of Faculty and Fitzrandolph Roads or other lots along Ivy Lane after 5:00 pm. (see http://m.princeton.edu/map/.) The seminar is free and open to the public. Reservations are encouraged for the seminar but required for dinner, which is $25 ($10 for students) and $22.50 ($10 for students) if prepaid with credit card (select “pay by debit or credit card”) or PayPal. Go to http://chemists.princeton.edu/pacs/event/princeton-acs-september-24-meeting/ for registration and payments. If you have questions, contact firstname.lastname@example.org.
PACS Receives ChemLuminary!
The ChemLuminary Awards poster session and awards presentation took place at the ACS Fall 2019 National Meeting & Expo in San Diego, CA on Tuesday, August 27, at the Manchester Grand Hyatt San Diego.
We are pleased to announce that the Section was awarded a ChemLuminary for “Outstanding On-going NCWEvent” sponsored by the Committee on Community Activities CCA). This was in recognition of our ongoing National Chemistry Week Activities Nights since 2000 and in particular the 2018 “Chemistry is Out of this World” Activities Night. Congratulations and thank you to Princeton Lecture Demonstrator in Chemistry, Dr. Kathryn Wagner for her commitment and hard work in organizing these events. Thank you also to all the volunteers who supported the program throughout the years!
PACS members Barbara Ameer, Mukund Chorghade, Louise Lawter and Randy Weintraub were present to receive the award from Luis Echegoyen, ACS President-Elect and CCA Chair, Holly Davis.
National Chemistry Week 2019 “Marvelous Metals” Activities Night October 25: Volunteers needed!
By Kitty Wagner, NCW Coordinator
Please join us for the 20th annual PACS NCW Activities Night on Friday, October 25, 6:30-9:30 pm, at Frick Chemistry Laboratory, Princeton University, Princeton, NJ 08544. This year’s theme is “Marvelous Metals.” We usually have 500+ guests and ~100 high school volunteers. We need adult volunteers!
There are many tasks to be done, before and during the event. Contact Kitty Wagner, email@example.com if any of the following interest you:
- (urgent!) Planning program. Share your ideas for safe metal-related demonstrations, displays, games, or hands-on activities for ages 5 and up
- Training volunteers before the event
- (urgent!!) Participating in an auditorium show demonstrating properties of metals that can’t be demonstrated in the Frick atrium or at close quarters in the gen chem labs. Auditorium presenters will need to meet at Frick before the event (to review safety procedures and practice presentation) and participate in at least one presentation on October 25. Participants in the first presentation will need to arrive by 6:00 pm. The last presentation will end by 9:30 pm. Short video clips may also be included in the presentations.)
- Supervising or facilitating activities. A sign-up sheet will be sent to everyone interested in early October. First shift starts at 6:00 pm to be ready for guests at 6:30 pm. Last shift ends at 9:30. Training and practice provided as necessary.
- Making signs and posters before the event
- Registration: 5:00-8:30 pm. Registration for 7:30 group starts at 7:00pm. Guests and volunteers may arrive throughout the evening.
- People and equipment management between 5:45-10:00 pm. Hand out materials, post guards, direct guests, manage goggles.
- Set-up: 3:30p-5:30 pm
- Clean-up 9:30-10:00 pm
Our volunteers make NCW Activities Nights possible. Many thanks to the veterans who have made PACS NCW Activities Night “Outstanding Ongoing NCW Event of 2018!” We hope to see you again this year. Welcome to the newbies! We hope you will enjoy carrying on the tradition.
News from National
Highlights of actions and reports from the ACS Council Meeting on August 28, 2019, and the Board of Directors meetings held August 23-25, 2019, at the 2019 ACS fall national meeting in San Diego, California. More information is also available at https://www.acs.org/content/acs/en/about/governance/councilors.html
Election Results: Elected Committees of Council
By electronic ballot, the Council elected Anne M. Gaffney, Lydia E. M. Hines, Will E. Lynch, and Sally B. Peters for three-year terms (2020-2022), and Dee Ann Casteel for a one-year term (2020) on the Council Policy Committee (CPC).
By electronic ballot, the Council elected Michelle V. Buchannan, Charles E. Cannon, Alan A. Hazari, Amber S. Hinkle, and Thomas H. Lane for three-year terms (2020-2022) on the Committee on Nominations and Elections (N&E).
By electronic ballot, the Council elected Lisa M. Balbes, D. Richard Cobb, Emilio X. Esposito, Jason E. Ritchie, and Stephanie J. Watson for three-year terms (2020-2022) on the Committee on Committees (ConC).
Establishment of an International Chemical Sciences Chapter
On the recommendation of the Committee on International Activities, and with the concurrence of the Council Policy Committee, Council approved the creation of an ACS International Chemical Sciences Chapter in the Republic of Georgia, contingent on approval by the Board of Directors.
Redistricting of a Local Section
On the recommendation of Nominations & Elections, the Council voted that the Pittsburgh Local Section be transferred from District II to District III in order to bring District III’s member population into compliance with bylaw requirements. (Note: The Princeton ACS Section is also a member of District III)
Highlights from Committee Reports
Budget and Finance – The Society’s 2019 financial performance through July 31st yielded a Net from Operations of $30.1 million. This is $10 million favorable to the Approved Budget, and $1.7 million less than the same period in 2018. Total revenues are right on budget at $338 million. Total expenses are $308 million, which is $10 million favorable to budget
The Board approved funding for the ChemIDP and the International Student Chapters Programs in the 2020 Proposed Budget.
The Board approved funding for the Green and Sustainable Chemistry Education Resources pilot for inclusion in the 2020 Proposed Budget.
The Society is expected to end the year in compliance with each of the five Board-established financial guidelines. Additional information can be found at www.acs.org, at the bottom of the page, click ‘About ACS’, then ‘Financial’.
- San Diego Meeting Attendance
As of Tuesday evening, August 27, attendance was:
- Attendees 7,488
- Students 3,095
- Exhibitors 995
- Expo only 430
- Guests 401
- Total 12,409
2019 Career Navigator live data
- Participating Employers 31
- Number of Open Positions 81
- Job Seeker Profiles 239
- Lightning Talk Attendees 270
- Career Pathway Registrations 1,180
- Career Consultant Interactions 555
Board of Directors Executive Session
At this meeting, the ACS Board of Directors focused on a number of key strategic issues and took several related actions.
•On the recommendation of the Society Committee on Budget and Finance, the Board voted to set the advance member registration fee for national meetings held in 2020 at $505 – this amount is equal to the 2019 fee, adjusted for inflation – and to approve or reauthorize several program funding requests.
•The Board liaison for globalization provided a summary of a recent Board survey and received additional feedback from the Board on the globalization vision for Society programs. The goal here is encouragement and expansion, where appropriate, of existing successful international activities and initiatives, as well as evaluating current products and programs; exploring additional options and opportunities; and advising the Board on the assembly of a coherent and balanced program portfolio appropriate to the globalized ACS of the twenty-first century.
PACS Elections for 2020 Officers
The election for 2020 Princeton ACS Section Chair-Elect, Secretary, Treasurer and Member-at-Large (2020-2021) will be taking place in October 2019.
We are seeking candidates to run for each of these offices. If you wish to nominate candidates (or self-nominate) go to post “Nominations for 2020 PACS Elections” on our website and complete the attached Form or click this link:http://chemists.princeton.edu/pacs/wp-admin/admin.php?page=gf_edit_forms&id=25
Serving in any of these leadership positions is an excellent way to develop and practice managerial and leadership skills. Newly elected Chair-elects are invited to attend the ACS Leadership Institute in January to receive training as a new Local Section leader. This includes taking two facilitated ACS Leadership Development System courses of their choice. A brief description of the responsibilities of each of these offices can be found in our By-Laws at http://chemists.princeton.edu/pacs/about/princeton-section-bylaws/
Submissions must be received by September 28, 2019. Candidates are required to be a member of the Princeton ACS Section.
There are many other ways to get more involved in the Section. To explore some of these, you can speak to our committee chairs, councilors or officers at one of our monthly meeting. Hope to see you at our next meeting on September 24!
Questions?Email Louise Lawter at firstname.lastname@example.org
2019 NCW Illustrated Poem Contest – Marvelous Metals
The Princeton Local Section of the American Chemical Society (ACS) is sponsoring an illustrated poem contest for students in Kindergarten through 8th grade in conjunction with National Chemistry week.
Contest Deadline: Poems and entry forms must be received by Friday, October 18, 2019.
Prizes: Prizes will be awarded in K-2nd; 3rd-5th and 6th-8th grades categories.
Contact: Mail or email submissions to Louise Lawter, 475 Prince William Ct., Yardley, PA 19067, email: email@example.com.
Winners of the Princeton Local Section’s Illustrated Poem Contest will advance to the National Illustrated Poem Contest for a chance to be featured on the ACS website and to win prizes!
Description – Write and illustrate a poem using the NCW theme, “Marvelous Metals”. Your poem must be no more than 40 words and in one of the following styles to be considered: Haiku, Limerick, Ode, ABC poem, Free verse, End rhyme, and Blank verse.Possible topics related to metals include: Alloys, Conductors, Electricity, Electrons, Magnetism, Metalloids, Minerals, Rust. Contest rules and entry forms can be found at: http://chemists.princeton.edu/pacs/community-outreach/2019-national-chemistry-week-ncw-illustrated-poem-contest/
Philadelphia Section of the ACS Career Event
The Art of Managing Scientists – Panel Discussion and Networking Event
Would you like to be a better manager of scientists? Are you transitioning into management, or considering making this transition? Come hear local experts discuss their transitions to management, and advice they’ve received that makes them better managers. The event will include time to network with fellow attendees as well as ask questions of the panelists.
Oct 16, 6:30-8:30 pm at Giant Community Center, Willow Grove, https://stores.giantfoodstores.com/pa/willow-grove/315-york-rd
Plenty of free parking, easily accessible from the PA turnpike, 10 min walk from the Willow Grove SEPTA station (Warminster line). Food and soft drinks will be provided
Questions: contact the organizers at firstname.lastname@example.org, or email@example.com
This is a free event, thanks to our sponsors: Philadelphia section of the American Chemical Society, Association of Laboratory Managers, and Arkema Inc.