Publications

2016-2017

Xiongyi Huang and John T. Groves, Taming Azide Radicals for Catalytic C-H Azidation, ACS Catalysis, 2016, 6, 751−759. DOI: 10.1021/acscatal.5b02474.

Hsieh, C. H., Huang, X., Keys, C. L. Groves, J. T., Austin, R. N., Makris, T. M., Mechanism and Catalytic Potential of a Cytochrome P450 (OleT) that Catalyzes C-C Bond Scission, FASEB J., 2016, 30, S608.3

Xiongyi Huang and John T. Groves, Beyond ferryl-mediated hydroxylation: 40 years of the rebound mechanism and C-H activation, J. Biol. Inorg. Chem. 2017, 22, 185–207 DOI 10.1007/s00775-016-1414-3.

Hongxin Gao and John T. Groves,  Fast Hydrogen Atom Abstraction by a Hydroxo Iron(III) Porphyrazine, J. Am. Chem. Soc. 2017, 139, 3938-3941, DOI: 10.1021/jacs.6b13091.

Wei Liu, Mu-Jeng Cheng, Robert J. Nielsen, William A. Goddard III, and John T. Groves, Probing the C-O bond-formation step in metalloporphyrin catalyzed C-H oxygenation reactions, ACS Catalysis, 2017, 7, 4182-4188, DOI: 10.1021/acscatal.7b00655

Chun H. Hsieh, Xiongyi Huang, José A. Amaya, Cooper D. Rutland, Carson L. Keys, John T. Groves, Rachel N. Austin, Thomas M. Makris The Enigmatic P450 Decarboxylase OleT is Capable of, but Evolved to Frustrate, Oxygen Rebound Chemistry, Biochemistry 2017, 56, 3347-3357.  DOI: 10.1021/acs.biochem.7b00338

Ross Fu, Robert J. Nielsen, Nichole A. Schwartz, William A. Goddard III, T. Brent Gunnoe, John T. Groves, DFT mechanistic study of methane monooxygenation by hypervalent iodine alkane oxidation (HIAO) process, ACS Catalysis, 2017, 7, in press.

Xiongyi Huang and John T. Groves, Oxygen activation and radical transformations in heme proteins and metalloporphyrins, Chem. Rev. 2017, in press.

Nichole A. Schwartz, Shunyan Gu, Bradley A. McKeown, Xiongyi Huang, Nicholas C. Boaz, T. Brent Gunnoe, John T. Groves, Studies of C­­­­-H Activation and Functionalization: Combined Computational and Experimental Efforts to Elucidate Mechanisms, Principles and Catalysts Springer, in review.

Xiongyi Huang, Thompson Zhuang, Patrick A. Kates, Hongxin Gao, Xinyi Chen, and John T. Groves, Alkyl Isocyanates via Manganese-Catalyzed C-H Activation for the Preparation of Substituted Ureas , J. Am. Chem. Soc. 2017, 139, DOI: 10.1021/jacs.7b07658

Wei Liu, Xiongyi Huang, Micheal Placzek, Shane W. Krska, Paul McQuade, Jacob M. Hooker, John T. Groves, Site-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrin, Chem. Sci., 2017, in press.

Gang Li, Andrew K. Dilger, Peter T. Cheng, William R. Ewing, John T. Groves, Selective C-H Halogenations with a Fluorinated Manganese Porphyrin, Angew. Chem. 2017, in press.

2015

Groves, J.T. Cytochrome P450 Enzymes: Understanding the Biochemical Heiroglyphs, F1000Research 2015, 4(F1000 Faculty Rev):178 [Full Text PDF]

Liu, W., Groves, J.T. Manganese-catalyzed C-H Halogenation, Accounts Chem. Res., 2015, 48, 1727-1735 [Full Text PDF]

Huang, X.; Bergsten, T.; Groves, J.T. Manganese-catalyzed Late-stage Aliphatic C-H Azidation, J. Am. Chem. Soc., 2015, 137, 5300-5303 [Full Text PDF]

Boaz, N.; Bell, S.R.; Groves, J.T. Ferryl Protonation in Oxoiron(IV) Porphyrins and its Role in Oxygen Transfer, J. Am. Chem. Soc., 2015, 137 (8), 2875-2885 [Full Text PDF]

Huang, X.; Liu, W.; Hooker, J.M.; Groves, J.T. Targeted Fluorination with ­­­Fluoride Ion via Manganese-Catalyzed Decarboxylation, Angew. Chem. Int. Ed., 2015, 54, 5241-5245 [Full Text PDF]

Wang, X.; Ullrich, R.; Hofrichter, M.; Groves, J.T. The Heme-thiolate Ferryl of Aromatic Peroxygenase is Basic and Reactive, Proc. Nat. Acad. Sci. U.S.A., 2015, 112 (12), 3686-3691 [Full Text PDF]

Kalman, S.E.; Munz, D.; Fortman, G.C.; Boaz, N.C.; Groves, J.T.; Gunnoe, B.T. Partial Oxidation of Light Hydrocarbons Using Periodate and Chloride Salts, Dalton Trans., 2015, 44, 5294-5298 [Full Text PDF]

2014

Stavniichuk, R.; Shevalye, H.; Lupachyk, S.; Obrosov, A.; Groves, J.T.; Obrosova, I.G.; Yorek, M.A. Peroxynitrite and Protein Nitration in the Pathogenesis of Diabetic Peripheral Neuropathy, Diabetes/Metabolism Research and Reviews, 2014, 30, 669-678 [Full Text PDF]

Konnick, M.M.; Hashiguchi, B.G.; Devarajan, D.; Boaz, N.C.; Gunnoe, B.T.; Groves, J.T.; Ess, D.H.; Periana, R.A. Selective CH Oxy-Functionalization of Methane, Ethane and Propane by a Perfluoroarene Iodine (III) Complex, Angew. Chem. Int. Ed., 201453, 10490-10494 [Full Text PDF]

Groves, J.T.; Boaz, N.C. Fishing for the Peroxidase Protons, Science, 2014, 345, 142-143 [Full Text PDF]

Groves, J.T. Enzymatic C-H Activation – Using Push to Get Pull, Nature Chemistry, 2014, 6, 89-91. [Full Text PDF]

O’Reilly, M.E.; Phals, D.R.; Webb, J.R.; Boaz, N.C.; Majumdar, S.; Hoff, C.D.; Groves, J.T.; Cundari, T.R.; Gunnoe, T.B. Reductive Functionalization of a Rhodium(III)-methyl Bond by Electronic Modification of the Supporting Ligand, Dalton Trans., 2014, 43(22), 8273-8281 [Full Text PDF]

Pahls, D.R.; Groves, J.T.; Gunnoe, B.T.; Cundari, T.R. Theoretical Study of Reductive Funcationalization of Methyl Ligands of Group 9 Complexes Supported by Two Bipyridyl Ligands: A Key Step in Catalytic Hydrocarbon Funcationalization, Organometallics, 2014, 33, 1936-1944. [Full Text PDF]

Huang, X.; Liu, W.; Ren, H.; Neelamegam, R.; Hooker, J.M.; Groves, J.T. Late Stage Benzylic C-H Fluorination with [18F] Fluoride for PET Imaging, J. Am. Chem. Soc., 2014, 136(19), 6842-6845  [Full Text PDF]

Fortman, G.C.; Boaz, N.C.; Konnick, M.M.; Periana, R.A.; Groves, J.T.; Gunnoe, B.T. Selective Mono-oxidation of Light Alkanes Using Chloride and Iodate, J. Am. Chem. Soc., 2014, 136(23), 8393-8401 [Full Text PD]

2013

Liu, W.; Huang, X., Groves, J.T. Oxidative Aliphatic C-H Fluorination with Manganese Catalysts and Fluoride Ion Nat. Protoc. 2013, 8 (12), 2348-2354. [Full Text PDF]

Bertrand, E.M.; Keddis, R.; Groves, J.T.; Vetriani, C.; Austin, R.N. Identity and Mechanisms of Alkane-oxidizing Metalloenzymes from Deep-sea Hydrothermal Vents Front. Microbiol. 2013, 4, 109.  [Full Text PDF]

Wang, D.; Groves, J.T. Efficient Water Oxidation Catalyzed by Homogeneous Cationic Cobalt Porphyrins with Critical Roles for the Buffer Base Proc. Nat. Acad. Sci. USA 2013, 39, 15579-15584. [Full Text PDF]

Wang, X.; Peter, S.; Ullrich, R.; Hofrichter, M.; Groves, J.T. Driving Force for Oxygen-Atom Transfer by Heme-Thiolate Enzymes  Agnew. Chem. Int. Ed. 2013, 52 (35), 9238-9241. [Full Text PDF]

Liu, W.; Groves, J.T. Mn-Catalyzed Oxidative Benzylic C-H Fluorination Using Fluoride Ion Angew. Chem. Int. Ed. 2013, 52 (23), 6024-6027 [Full Text PDF]

Bergstrom, C.L.; Beales, P.A.; Lv, Y.; Vanderlick, T.K.; Groves, J.T.  Cytochrome Causes Pore Formation in Cardiolipin-Containing Membranes Proc. Nat. Acad. Sci. U.S.A.2013, 110 (16), 6269-6274  [Full Text PDF]

Naing, S.-H.; Parvez, S.; Pender-Cudlip, M.; Groves, J.T.; Austin, R.N. Sustrate Specificity and Reaction Mechanism of Purified Alkane Hydroxylase from the Hydrocarbonoclastus Bacterium Alcanivorax Borkumensis (AbAlkB) J. Inorg. Biochem. 2013, 121, 46-52.  

2012

Cooper, H.L.R.; Mishra, G.; Huang, X.; Pender-Cudlip, M.; Austin, R.N.; Shanklin,J.; Groves, J.T. Parallel and Competitive Pathways for Substrate Desaturation, Hydroxylation and Radical Rearrangement by the Non-heme Diiron Hydroxylase AlkB J. Am. Chem. Soc. 2012, 134(50), 20365-20375 [Full Text PDF]

 Liu, W.; Huang, X.; Cheng, M.-J.; Nielsen, R.J.; Goddard, W.A., III; Groves, J.T. Oxidative Aliphatic C-H Fluorination with Fluoride Ion Catalyzed by a Manganese Porphyrin Science 2012, 337, 1322-1325 [Full Text PDF]

 Pouy, M.J.; Milczek, E.M.; Figg, T.M.; Otten, B. Flavin-Catalyzed Insertion of Oxygen into Rhenium-Methyl Bonds J. Am. Chem. Soc. 2012, 134(31), 12920-12923 [Full Text PDF]

 Wang, X.; Peter, S.; Kinne, M.; Hofrichter, M.; Groves, J.T. Detection and Kinetic Characterization of a Highly Reactive Heme-Thiolate Peroxygenase Compound I J. Am. Chem. Soc. 2012, 134, 12897-12900 [Full Text PDF]

 Szabo, G.; Loganathan, S.; Merkely, B.; Groves, J.T.; Karck, M.; Szabo, C.; Radovits, T. Catalytic Peroxynitrite Decomposition Improves Reperfusion Injury After Heart Transplantation J. Thorac Cardiovasc Surg 2012, 143(6), 1443-1449 [Full Text PDF]

Radovits, T.; Beller, C.J.; Groves, J.T.; Merkely, B.; Karck, M.; Szabo, C.; Szabo, G. Effects of FP15, a Peroxynitrite Decomposition Catalyst on Cardiac and Pulmonary Function After Cardiopulmonary Bypass Eur. J. Cardiothorac Surg 2012, 41, 391-396. [Full Text PDF]

2011

Umile, T.P., Groves, J.T. Dissection of the Mechanism of Manganese Porphyrin-Catalyzed Chlorine Dioxide Generation Inorg. Chem. 2011, 50(20), 10353-10362 [Full Text PDF]

Austin, R.N.; Groves, J.T. Alkane-oxidizing Metalloenzymes in the Carbon Cycle Metallomics 2011, 3, 751-854 [Full Text PDF]

Callaghan, A.V.; Morris, B.E.L.; Pereir, A.C.; McInerney, M.J.; Austin, R.N.; Groves, J.T.; Kukor, J.J.; Suflita, J.M.; Young, L.Y.; Zylstra, G.J.; Wawrik, B. The Genome Sequence of Desulfatibacillum alkenivorans AK-01: A Blueprint for Anaerobic Alkane Oxidation Environ. Microbiol. 2011, 44, 7287-7294 [Full Text PDF]

Golisz, S.R.; Gunnoe, T. B.; Goddard, III, W.A.; Groves, J.T.; Periana, R.A. Chemistry in the Center for Catalytic Hydrocarbon Functionalization: An Energy Frontier Research Center Catal. Lett. 2011, 2, 213-221 [Full Text PDF]

Beales, P.A.; Bergstrom, C.L.; Groves, J.T.; Vanderlick, T.K. Single Vesicle Observations of the Cardiolipin-Cytochrome c Interaction: Induction of Membrane Morphology Changes Langmuir 2011, 27, 6107-6115 [Full Text PDF]

Umile, T.; Groves, J.T. Catalytic Generation of Chlorine Dioxide from Chlorite Using a Water-soluble Manganese Porphyrin Angew. Chem. 2011, 50(3), 721-724 [Full Text PDF]

2010

Cooper, H.L.R..; Groves, J.T. Molecular Probes of the Mechanism of Cytochrome P450. Oxygen Traps a Substrate Radical Intermediate Arch. Biochem. Biophys. 2011, 507, 111-118. [Full Text PDF]

Surmeli, N.B..; Groves, Peroxynitrite Medidates Active Site Tyrosine Nitration in Manganese Superoxide Dismutase. Evidence of a Role for the Carbonate Radical Anion J. Am. Chem. Soc. 2010, 132, 17174-17185. [Full Text PDF]

Umile, T.; Groves, J.T. A “Push-Pull” Mechanism for Heterolytic O-O Bond Cleavage in Hydroperoxo Manganese Porphyrins Inorg. Chem. 2010, 24, 11516-11524 [Full Text PDF]

Su, J.; Groves, J.T. Mechanisms of Peroxynitrite Interactions with Heme Proteins Inorg. Chem. 2010, 49, 6317-6329 [Full Text PDF]

Liu, W.; Groves, J.T. Manganese Porphyrins Catalyze C-H Bond Halogenations J. Am. Chem. Soc. 2010, 132(37), 12847-12849. [Full Text PDF]

2009

Bell, S.; Groves, J.T. A Highly Reactive P450 Model Compound J. Am. Chem. Soc. 2009, 131(28), 9640-9641. (PMCID2760262) [Full Text PDF]

Su, J.; Groves, J.T. Direct Detection of the Oxygen Rebound Intermediates, Ferryl Mb and NO2 in the Reaction of met Myoglobin with Peroxynitrite J. Am. Chem. Soc. 2009, 131(36), 12979-12988. [Full Text PDF]

2008

Austin, R.N.; Luddy, K.; Erickson, K.; Pender-Cudlip, M.; Bertrand, E.; Deng, D.; Buzdygon, R.S.; van Beilen, J.B.; Groves, J.T.; Cage escape competes with geminate recombination during alkane hydroxylation by the diiron oxygenase AlkB. Angew. Chem. 2008, 47(28), 5232-5234. (PMID: 18512839) [Full Text PDF] [Abstract and TOC figure]

2007

Pavlov, I.; Vareniuk, I.; Drel, V.R.; Lyzogubov, V.; Ilnytska, O.; Mashtalir, N.; Tibrewala, J.; Groves, J.T.; Obrosova, I. Nitrosative stress and neuropathy in mouse models of type 1 and type 2 diabetes. Diabetes 2007, 56, A207.

Obrosova, I.G.; Drel, V.R.; Oltman, C.L.; Mashtalir, N.; Tibrewala, J.; Groves, J.T.; Yorek, M.A. Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats. Am. J. Physiol. Endocrinol. Metab. 2007, 293(6) E1645-E1655. (PMID: 17911342) [Full Text PDF]

Drel, V.R.; Pacher, P.; Vareniuk, I.; Pavlov, I.; Ilnytska, O.; Lyzogubov, V.V.; Bell, S.R.; Groves, J.T.; Obrosova, I.G. Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetramesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes. International Journal of Molecular Medicine 2007, 20(6), 783-792. (PMCID2527588) [Full Text PDF]

Jin, N.; Ibrahim, M.; Spiro, T.G.; Groves, J.T. Trans-dioxo manganese(V) porphyrins. J. Am. Chem. Soc. 2007, 129(41), 12416. (Highlighted in Angew. Chem. Int. Ed. Engl. 2008, 47(15), 2737-9, The Groves-Spiro Dioxomanganese(v) Story). (PMCID2773832) [Full Text PDF] [Abstract and TOC figure]

Lahaye, D.; Groves, J.T. Modeling the haloperoxidases. Reversible oxygen atom transfer between bromide ion and an oxo-mn(V) porphyrin J. Inorg. Biochem. 2007, 101(11-12), 1786-1797. (PMID: 17825916) [Full Text PDF]

Drel, V.R.; Pacher, P.; Vareniuk, I.; Pavlov, I.; Ilnytska, O.; Lyzogubov, V.V.; Tibrewala, J.; Groves, J.T.; Obrosova, I.G. A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice Eur. J. Pharmacol. 2007, 569(1-2), 48-58. (PMCID: PMC2225472) [Full Text PDF]

Chakrabarty, S.; Austin, R.N.; Deng, D.; Groves, J.T.; Lipscomb, J.D. Radical intermediates in monooxygenase reactions of rieske dioxygenase J. Am. Chem. Soc. 2007, 129(12), 3514-3515. (PMID: 17341076) [Full Text PDF]

Dismukes, G.C.; Hecht, M.; Spiro, T.G.; Groves, J.T.; Chianelli, R.R. Remembering Edward I. Stiefel J. Inorg. Biochem. 2007, 110, vii-viii. [Full Text PDF]

Vareniuk, I.; Pavlov, I.A.; Drel, V.R.; Lyzogubov, V.V.; Ilnytska, O.; Bell, S.R.; Tibrewala, J.; Groves, J.T.; Obrosova, I.G. Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice Exp. Neurol. 2007, 205, 425-436. DOI: 10.1016/j.expneurol.2007.03.019 [Full Text PDF]

Rozhkova-Novosad, E.A.; Chae, J.C.;
Zylstra, G.J.; Bertrand, E.M.; Deng, D.; Moe, L.; van Bielen, J.B.; Alexander-Ozinskas, M.; Danahy, M.; Groves, J.T.; Austin, R.N. Profiling mechanisms of alkane hydroxylase activity in vivo using the diagnostic substrate norcarane. Chem. Biol. 2007, 14, 165-172. [Full Text PDF]

Balakrishnan, G.; Hu, Y.; Oyerinde, O.F.; Su, J.; Groves, J.T.; Spiro, T.G. A conformational switch to ß-sheet structure in cytochrome c leads to heme exposure; implications for cardiolipin peroxidation and apoptosis. J. Am. Chem. Soc. 2007,
129(3), 504-505. (PMCID2596592) [Full Text PDF]

Radovits, T.; Seres, L.; Gerö, D.; Lin., L.; Beller, C.J.; Chen, S.-H.; Zotkina, J.; Berger, I.; Groves, J.T.; Szabó, C.; Szabó, G. The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction. Mechanisms of Ageing and Development 2007, 128(2), 173-181. [Full Text PDF]

2006

Morel, F.M.M.; Groves, J.T. Edward I. Stiefel (1942-2006) a Retrospective Science 2006, 314, 1406. [Full Text PDF]

Datta, A.; Quintavalla, S.M.; Groves, J.T. Kinetic selectivity in the N-alkylation of 2-pyridyl porphyrins: a facile approach to the α β β-scaffold. J. Org. Chem. 2006, 72(5), 1818-1821. DOI:10.1021/jo062017r. [Full Text PDF]

Austin, R.N.; Deng, D.; Jiang, Y.; Luddy, K.; van Beilen, J.B.; Ortiz de Montellano, P.R.; Groves, J.T. The diagnostic substrate bicyclohexane reveals a radical mechanism for bacterial cytochrome P450 in whole cells Angew. Chem. 2006, 45(48), 8192-8194. [Full Text PDF]

Groves, J.T. High-valent iron in chemical and biological oxidations. J. Inorg. Biochem. 2006, 100(4), 434-447. [Full Text PDF]

Wang, C.; Shalyaev, K.V.; Bonchio, M.; Carofiglio, T.; Groves, J.T. Fast catalytic hydroxylation of hydrocarbons with ruthenium porphyrins Inorg. Chem. 2006, 45(10), 4769-4782. [Full Text PDF]

DeAngelis, F.; Jin, N.; Car, R.; Groves, J.T. Electronic structure and reactivity of isomeric oxo-Mn(V) porphyrins: Effects of spin-state crossing and pK(a) modulation Inorg. Chem. 2006, 45(12), 4268-4276. [Full Text PDF]

Puranik, M.; Weeks, C.L.; Lahaye, D.; Kabil, O.; Taoka, S.; Nielsen, S.B.; Groves, J.T.; Banerjee, R.; Spiro, T.G. Dynamics of carbon monoxide binding to cystathionine β-synthase J. of Biol. Chem. 2006, 281(19), 13433-13438. [Full Text PDF]

Han, Y.-Z.; Sanford, M.S.; England, M.D.; Groves, J.T. Mechanistic studies of an unusual epoxide-forming elimination of a β-hydroxyalkyl rhodium porphyrin Chem. Commun. 2006, 5, 549-551. [Full Text PDF]

Luo, M.; Lin, H.; Fischbach, M.A.; Liu, D.R.; Walsh, C.T.; Groves, J.T. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition ACS Chem. Biol. 2006, 1(1), 29-32. [Full Text PDF]

2005

Obrosova, I.G.; Mabley, J.G.; Zsengellér, Z.; Charniauskaya, T.; Abatan, O.I.; Groves, J.T. Szabó, C. Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst The FASEB J. 2005, 19(3), 401-3. [Full Text PDF]

Luo, M.; Fadeev, E.A.; Groves, J.T. Membrane dynamics of the amiphiphilic siderophore, acinetoferrin J. Am. Chem. Soc., 2005, 127, 1726-1736. [Full Text PDF]

Fadeev, E.A.; Luo, M.; Groves, J.T. Synthesis and structural modeling of the amphiphilic siderophore rhizobactin-1021 and its analogs Bioorg. Med. Chem. Lett. 2005, 15, 3771-3774. [Full Text PDF]

Luo, M.; Fadeev, E.A.; Groves, J.T. Mycobactin-mediated iron acquisition within macrophages Nature Chem. Biol. 2005, 1, 149-153. [Full Text PDF]

Bertrand, E.; Sakai, R.; Rozhkova-Novosad, E.; Moe, L.; Fox, B.G.; Groves, J.T.; Austin, R.N. Reaction mechanisms of non-heme diiron hydroxylases characterized in whole cells J. Inorg. Biochem. 2005, 99(10), 1998-2006. [Full Text PDF]

Groves, J.T. Models and Mechanisms of Cytochrome P-450 Action In Cytochrome P450: Structure, Mechanism and Biochemistry; Ortiz de Montellano, P.R. Ed.; Kluwer Academic/Plenum Publishers: New York, 2005, pp. 1-44.

2004

Moe, L.A.; Hu, Z.; Deng, D.; Austin, R.N.; Groves, J.T.; Fox, B.G. Remarkable aliphatic hydroxylation by the diironenzyme toluene 4-monooxygenase in reactions with radical/cation diagnostic probes norcarane, 1, 1-dimethylcyclopropane, and 1,1-diethylcyclopropane Biochemistry 2004, 43, 15688-15701. [Full Text PDF]

Puranik, M.; Nielsen, S.B.; Youn, H.; Hvitved, A.N.; Bourassa, J.L.; Case, M.A.; Tengroth, C.; Balakrishnan, G.; Thorsteinsson, M.V.; Groves, J.T.; McLendon, G.L.; Roberts, G.P.; Olson, J.S.; Spiro, T.G. Dynamics of carbon monoxide binding to CooA J. Biol. Chem. 2004, 279, 21096-21108. [Full Text PDF]

Fadeev, E.A.; Luo, M.; Groves, J.T. Synthesis, structure and molecular dynamics of iron and gallium complexes of schizokinen and the amphiphilic siderophore acinetoferrin J. Am. Chem.Soc. 2004, 126(38), 12065-12075. [Full Text PDF]

Zhou, H.; Groves, J.T. Host-guest interactions of cyclodextrins and metalloporphyrins: Supramolecular building blocks toward artificial heme proteins J. Porphyrins Phthalocyanines 2004, 8, 125-140.

Sanford, M.S.; Groves, J.T. Ant-Markovnikov hydrofunctionalization of olefins mediated by rhodium porphyrins Angew. Chemie 2004, 116, 598-600. [Full Text PDF]

2003

Soriano, F.G.; Liaudet, L.; Mabley, J.G.; Salzman, A.L.; Groves, J.T.; Szabo C. Role of peroxynitrite in the pathogenesis of endotoxic and septic shock in rodents FASEB J. 2003, 17(5), A1069-A1070 Part 2 Suppl.

Pacher, P.; Liaudet, L.; Mabley, J.G.; Kaminski, P.M.; Virag, L.; Deb, A.; Ungvari, Z.; Wolin, M.S.; Groves, J.T.; Szabo, C. Role of superoxide, NO and peroxynitrite in doxorubicin-induced cardiac dysfunction FASEB J. 2003, 17(4), A229-A229 Part 1 Suppl.

Naidu, B.V.; Farivar, A.S.; Woolley, S.M.; Fraga, C.; Salzman, A.L.; Szabo, C.; Groves, J.T.; Mulligan, M.S. Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis Exp. Mol. Pathol. 2003, 75(1), 12-17. [Full Text PDF]

Phillips-McNaughton, K.; Groves, J.T. Zinc-Coordination oligomers of phenanthrolinylporphyrins Org. Lett. 2003, 5(11), 1829-1832. [Full Text PDF]

Austin, R.N.; Buzzi, K.; Kim, E.; Zylstra, G.J.; Groves, J.T. Xylene monooxygenase, a membrane-spanning non-heme diiron enzyme that hydroxylates hydrocarbons via a substrate radical intermediate
J. Biol. Inorg. Chem. 2003, 8, 733-739. [Full Text PDF]

Pacher, P.; Liaudet, L.; Bai, P.; Mabley, J.G.; Kaminsk, P.M.; Virág, L.; Deb, A.; Szabó, E.; Ungvári, Z.; Wolin, M.S.; Groves, J.T.; Szabó, C. A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction Circulation 2003, 107,(6), 896-904. [Full Text PDF]

Groves, J.T. The bioinorganic chemistry of iron in Oxygenases and supramolecular assemblies Proc. Nat. Acad. Sci. U.S.A. 2003, 100, 3569-3574. [Full Text PDF]

2002

Mabley, J.G.; Liaudet, L.; Pacher, P.; Southan, G.; Groves, J.T.; Salzman, A.L.; Szabó, C. Beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis
Molecular Medicine 2002, 8(10), 581-590. [Full Text PDF]

Szabo, C.; Mabley, J.G.; Moeller, S.M.; Shimanovich, R.; Pacher, P.; Virag, L.; Soriano, F.G.; Van Duzer, J.H.; Williams, W.; Salzman, A.L.; Groves, J.T. Pathogenicrole of peroxynitrite in the development of diabetes and diabetic vascular complications: Studies with FP15, a novel, potent peroxynitrite decomposition catalyst Molecular Medicine 2002, 8(10), 571-–580 [Full Text PDF]

Szabo, C.; Mabley, J.G.; Moeller, S.M.; Shimanovich, R.; Groves, J.T. FP 15, a novel, potent peroxynitrite decomposition catalyst: in vitro cytoprotective actions and protection against diabetes mellitus and diabetic cardiovascular complications FASEB J. 2002, 16, A1166.

Groves, J.T.; Moeller, S. Peroxynitrite decomposition catalysts and methods of use thereof. U.S. Patent 6,448,239, 2002.

Xu, G.; Martinez, J.; Groves, J.T.; Butler, A. Membrane affinity of the amphiphilic marinobactin siderophores J. Am. Chem. Soc. 2002, 124(45), 13408-13415.[Full Text PDF]

Auclair, K.; Hu, Z.; Little, D.M.; Ortiz de Montellano, P.R.; Groves, J.T. Revisiting the mechanism of P450 enzymes using the radical clocks norcarane and Spiro[2,5]octane J. Am. Chem Soc. 2002, 124, 6020-6027. [Full Text PDF]

Sauve, A.A.; Groves, J.T. Synthesis of trithiolanes and tetrathianes from thiiranes catalyzed by ruthenium salen nitrosyl complexes J. Am. Chem. Soc. 2002, 124, 4770-4778. [Full Text PDF]

2001

Brazeau, B.J.; Austin, R.N.; Tarr, C.; Groves, J.T.; Lipscomb, J.D. Intermediate Q from soluble methane monooxygenase hydroxylates the mechanistic substrate probe norcarane: Evidence for a stepwise reaction J. Am. Chem. Soc. 2001, 123, 11831-11837. [Full Text PDF]

Groves, J.T.; Austin, R.N.; Chang, H.K.; Zylstra, G.J. The non-heme diiron alkane monooxygenase of Pseudomonas oleovorans (AlkB) hydroxylates via a substrate radical intermediate J. Inorg. Biochem. 2001, 86, 54-54.

Ogliaro, F.; de Visser, S.P.; Groves, J.T.; Shaik, S. Chameleon states: High-valent metal-oxo species of cytochrome P450 and its ruthenium analog Angew. Chem. 2001, 40, 2874-2878.

Bourassa, J.L.; Ives, E.P.; Marqueling, A.L.; Shimanovich, R.; Groves, J.T. Myoglobin catalyzes its own nitration J. Am. Chem. Soc., 2001, 123, 5142-3. [Full Text PDF]

McMahon, B.; Frauenfelder, H.; Austin, R.; Chu, K.; Groves, J.T. The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin Biophys. J. 2001, 286a. [Full Text PDF]

Xu, G.; Wang, W.; Groves, J.T.; Hecht, M.H. Continuous thin films of protein β-sheets from a combinatorial library. Proc. Nat. Acad. Sci. U.S.A 2001, 98, 3652-57. [Full Text PDF]

Frauenfelder, H.; McMahon, B.H.; Austin, R.A.; Chu, K.; Groves, J.T. The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin. Proc. Nat. Acad. Sci. U.S.A. 2001, 98, 2370-2374. [Full Text PDF]

Shimanovich, R.; Groves, J.T. Mechanisms of peroxynitrite decomposition catalyzed by FeTMPS, a bioactive sulfonated iron porphyrin. Arch. Biochem. Biophys. 2001, 387, 307-317. [Full Text PDF]

Shimanovich, R.; Niezgoda, S.; Lynch, V.; Gerasimchuk, N.N.; Mody, T.; Magda, D.; Sessler, J.; Groves, J.T. Mn(II)-Texaphyrin as a catalyst for the decomposition of peroxynitrite. J. Am. Chem. Soc. 2001, 123, 3613-3614. [Full Text PDF]

Xu, G.; Aksay, I.A.; Groves, J.T. Continuous crystalline dahllite thin films via inhibited template assembly. J. Am. Chem. Soc. 2001, 123, 2196-2203. [Full Text PDF]

2000

Austin, R.N.; Chang, H.-K.; Zylstra, G.J.; Groves, J.T. The non-heme diiron alkane monooxygenase of pseudomonas oleovorans (AlkB) hydroxylates via a substrate radical intermediate. J. Am. Chem. Soc. 2000, 122, 11747-11748. [Full Text PDF]

Jin, N.; Bourassa, J.L.; Tizio, S.C.; Groves, J.T. Rapid, reversible oxygen atom transfer between an oxomanganese(V) porphyrin and bromide. A haloperoxidase mimic with enzymatic rates. Angew. Chem. 2000, 39, 3849-3851.

Groves, J.T.; Wang, C.C.-Y. Nitric oxide synthase: models and mechanisms. Curr. Opinion in Chem. Biol. 2000, 4, 687-695. [Full Text PDF]

Xu, G.; Yao, N.; Aksay, I.A.; Groves, J.T. An amorphous to crystalline transition in the formation of CaCO3 thin films. Proc. Microsc. Microanal., 2000, 6 Suppl. [2], 1072-73.

Xu, G.; Yao, N.; Aksay, I.A.; Groves, J.T. Synthesis of CaCO3 thin films via a bioinspired pathway: Cooperative template-inhibition. Proc. Microsc. Microanal. 2000, 6 Suppl. [2], 1070-71.

Groves, J.T. Reactivity and mechanisms of oxometalloporphyrin-catalyzed oxidations. J. Porphyrins Phthalocyanines2000, 4, 350-352. [Full Text PDF]

Xu, G.; Bao, Z.; Groves, J.T. Langmuir-Blodgett films of regioregular Poly(3-hexylthiophene) as field-effect transistors. Langmuir 2000, 16, 1834-41. [Full Text PDF]

1999

Groves, J.T.; Lee, J.; Hunt, J.A.; Shimanovich, R.; Jin, N.; Mechanisms of metalloporphyrin reactions with peroxynitrite. J. Inorg. Biochem. 1999, 74, 28.

Wang, C.C.-Y.; Ho, D.M.; Groves, J.T. Models of nitric oxide synthase: Iron(III)porphyrin-catalyzed oxidation of fluorenone oxime to nitric oxide and fluorenone. J. Am. Chem. Soc. 1999, 121, 12094-12103. [Full Text PDF]

Groves, J.T.; Carofiglio, T.; Bonchio, M.; Sauve, A. Catalytic oxygenation of hydrocarbons by metalloporphyrin and metallosalen complexes. U.S. Patent US1996000760849, 1999

Groves, J.T.; Shalyaev, K.; Lee, J. Oxometalloporphyrins in Oxidative Catalysis. In The Porphyrin Handbook; Kadish, K.M., Smith, K.M., Guilard, R., Eds.; Academic Press: San Diego, CA and Burlington, MA, 1999, Vol. 4, Ch. 27, pp 17-40.

Groves, J.T. Peroxynitrite: Reactive, invasive and enigmatic. Curr. Opinion in Chem. Biol. 1999, 3, 226-235. [Full Text PDF]

Jin, N.; Groves, J.T. Unusual kinetic stability of a ground sate singlet oxomanganese(V) porphyrin. Evidence for a spin state crossing effect. J. Am. Chem. Soc. 1999, 121, 2923-2924. [Full Text PDF]

1998

Xu, G.; Yao, N.; Aksay, I.A.; Groves, J.T. Biomimetic synthesis of macroscopic scale calcium carbonate thin films. Evidence for a multistep process. J. Am. Chem. Soc. 1998, 120, 11977-11985.

McLain, J.; Lee, J.; Groves, J.T. Biomimetic Oxygenations Related to Cytochrome P450. Metal-oxo and Metal-peroxo Intermediates. In Biomimetic Oxidations, Meunier, B., Ed.; ICP Publishers: 1999, Ch. 3. pp 91-170.

Lee, J.; Hunt, J.A.; Groves, J.T. Mechanisms of iron porphyrin reactions with peroxynitrite. J. Am. Chem. Soc. 1998, 120, 7493-7501.

Lee, J.; Hunt, J.A.; Groves, J.T. Manganese porphyrins as redox-coupled peroxynitrite reductases. J. Am. Chem. Soc. 1998, 120, 6053-61.

Groves, J.T.; Crowley, S.J.; Shalyaev, K.V. Paramagnetic 1H-NMR relaxation probes of stereoselectivity in metalloporphyrin catalyzed olefin epoxidation. Chirality 1998, 10, 106-119.

1997

Marla, S.S.; Lee, J.; Groves, J.T. Peroxynitrite rapidly permeates phospholipid membranes. Proc. Nat. Acad. Sci. U.S.A. 1997, 94, 14243.

Lee, J.; Hunt, J.A.; Groves, J.T. Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox-couples. Bioorg. Med. Chem. Lett. 1997, 7, 2913-18.

Hunt, J.A.; Lee, J.; Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chemistry and Biology 1997,, 4, 845-858.

Groves, J.T.; Wang, C.Y.; Models for nitric oxide synthase. FASEB J. 1997, 11, A769.

Groves, J.T. Artificial enzymes: The importance of being selective. Nature 1997,, 389, 329-330.

Groves, J.T.; Shalyaev, K.V.; Bonchio, M.; Carofiglio, T. Rapid Catalytic Oxygenation of Hydrocarbons with Perhalogenated Ruthenium Porphyrin Complexes. In Studies in Surface Science and Catalysis; Proceedings of the Third World Congress on Oxidation Catalysis, San Diego, CA, 1997; Grasselli, R.K., Oyama, S.T., Gafney, A.M., Lyons, J.E., Eds.; Elsevier: Amsterdam, 1997, Vol. 110, 865-872.

Groves, J.T.; Lee, J.; Marla, S. Detection and characterization of an oxo-anganese(V) porphyrin complex by rapid-mixing stopped-flow spectrophotometry. J. Am. Chem. Soc. 1997, 119, 6269-6273.

Lahiri, J.; Xu, G.; Dabbs, D.M.; Yao, N.; Aksay, I.A.; Groves, J.T. Designed amphiphilic porphyrin templates for the oriented nucleation of calcium carbonate. J. Am. Chem. Soc. 1997, 119, 5449-50.

1996

Groves, J.T. Multi-heme self-assembly and electron transfer in phospholipid vesicles. Photochem. Photobiol. 1996, 63, 21.

Groves, J.T.; Matsunaga, A. Designed double strand cleavage of DNA by metalloporphyrins. Bioorg. Med. Chem. Lett. 1996, 6, 1595-1600.

Lahiri, J.; Xu, G.; Lee, T.; Dabbs, D.M.; Yao, N.; Aksay, I.A.; Groves, J.T. Biomimetic Fabrication of Materials – The Minimalist Approach. In Smart Materials Technologies and Biomimetics, Proceedings of the International Society for Optical Engineering, San Diego, CA, 1996; Crowson, A., Ed.;
Vol. 2716, 317-323.

Aksay, I.A.; Groves, J.T.; Gruner, S.M.; Lee, P.C.Y.; Prud’homme, R.K.; Shih, W.-H.; Torquato, S.; Whitesides, G.J. Smart Materials Systems Through Mesoscale Patterning. In Smart Materials Technologies and Biomimetics, Proceedings of the International Society for Optical Engineering, San Diego, CA, 1996; Crowson, A., Ed.; Vol. 2716, 280-288.

Baum, E.Z.; Ding, W.-D.; Siegel, M.M.; Hulmes, J.; Bebernitz, G.A.; Sridharan, L.; Tabei, K.; Krishnamurthy, G.; Carofiglio, T.; Groves, J.T.; Bloom, J.D.; DiGrandi, M.; Bradley, M.; Ellestad, G.; Seddon, A.P.; Gluzman, Y. Flavins inhibit human cytomegalovirus UL80 protease via disulfide bond formation. Biochemistry 1996, 35, 5847-55.

Groves, J.T.; Bonchio, M.; Carofiglio, T. Rapid catalytic oxygenation of hydrocarbons by ruthenium porphyrin complexes. J. Am. Chem. Soc. 1996, 118, 8961.

Lahiri, J.; Fate, G.D.; Ungashe, S.; Groves, J.T. Multi-heme self-assembly in phospholipid vesicles. J. Am. Chem. Soc. 1996, 118, 2347-2358.

1995

Groves, J.T.; Marla, S. Peroxynitrite-induced DNA strand scission mediated by a manganese porphyrin. J. Am. Chem. Soc. 1995, 117, 9578.

Groves, J.T.; Roman, J.S. Nitrous oxide activation by a ruthenium porphyrin. J. Am. Chem. Soc. 1995, 117, 5594.

Groves, J.T.; Han, Y.-Z. Models and Mechanisms of Cytochrome P-450 Action. In Cytochrome P-450, 2nd ed.; Ortiz De Montellano, P., Ed.; 1995; pp 1-45.

Groves, J.T.; Gross, Z. On the Mechanism of Epoxidation and Hydroxylation Catalyzed by Iron Porphyrins. Evidence for Non-Intersecting Reaction Pathways. In Bioinorganic Chemistry: An Inorganic Perspective of Life; Kessissoglou, D.P., Ed.; NATO ASI Series 459;
Kluwer Academic Publishers: Dordrecht, 1995; pp 39-47.

Kim, R.M.; Fate, G.D.; Gonzáles, J.E.; Lahiri, J.; Ungashe, S.B.;
Groves, J.T. Self-assembly, Catalysis and Electron Transfer with Metalloporphyrins in Phospholipid Membranes. In Bioinorganic Chemistry: An Inorganic Perspective of Life; NATO ASI Series, 459; Kessissoglou, D.P., Ed.; Kluwer Academic Publishers: Dordrecht, 1995; pp 49-56.

1994

Ahn, K.-H.; Groves, J.T. Shape selective oxygen transfer to olefins catalyzed by sterically hindered iron porphyrins. Bull. Korean Chem. Soc. 1994, 15(11), 957-961.

Choma, C.T.; Kaestle, K.; Kim, R.M.; Åkerfeldt, K.S.; Groves, J.T.; DeGrado, W.F. A general method for coupling unprotected peptides to bromoacetamido porphyrin templates. Tetrahedron Lett. 1994, 35(34), 6191.

Groves, J.T.; Fate, G.; Lahiri, J. Directed multi-heme-self-assembly and electron transfer in a model membrane. J. Am. Chem. Soc. 1994, 116, 5477-5478.

Groves, J.T.; Gross, Z. Preparation and reactivity of oxoiron(IV) porphyrins. Inorg. Chem. 1994, 33, 5065-5072.

1993

Kim, R.M.; Pillon, J.E.; Burwell, D.A.; Groves, J.T.; Thompson, M.E. Intercalation of aminophenyl-and pyridinium-substituted porphyrins into zirconium hydrogen phosphate: Evidence for substituent-derived orientational selectivity. Inorg. Chem. 1993, 32, 4509- 4516.

Kady, I.O.; Groves, J.T. Synthesis of iron-binding oligonucleotides and their reactions with single-stranded DNA. Bioorg. Med. Chem. Lett. 1993, 3(6), 1367-1370.

Groves, J.T.; Kady, I.O. Sequence-specific cleavage of DNA by oligonucleotide-bound metal complexes. Inorg. Chem. 1993, 32, 3868-3872.

Ungashe, S.B.; Groves, J.T. Porphyrins and metalloporphyrins in synthetic bilayer membranes. In Advances in Inorganic Biochemistry, Marzilli, L.G., Ed.; Academic Press: 1993; Vol. 9, pp. 318-351.